接触农药与注意力缺陷多动障碍或自闭症谱系障碍之间的关联：文献系统综述
Association Between Exposure to Pesticides and ADHD or Autism Spectrum Disorder: A Systematic Review of the Literature.
作者信息
Tessari Luca, Angriman Marco, Díaz-Román Amparo, Zhang Junhua, Conca Andreas, Cortese Samuele
机构信息
Child and Adolescent Psychiatry Unit, Bolzano, Italy.
Hospital of Bolzano, Bolzano, Italy.
出版信息
J Atten Disord. 2022 Jan;26(1):48-71. doi: 10.1177/1087054720940402. Epub 2020 Jul 22.
OBJECTIVE
To conduct a systematic review of studies assessing the relationship between exposure to pesticides and ADHD or Autism Spectrum Disorder (ASD).
METHODS
Based on a pre-registered protocol in PROPSERO (CRD42018107847), we searched PubMed, Ovid databases, and ISI Web of Knowledge with no date/language/document type restrictions, up to May 2019. The Newcastle Ottawa Scale was used to assess study quality.
RESULTS
Among the 29 retained studies, 13 focused on ADHD, 14 on ASD, and two on both disorders. Ten studies reported a significant association between exposure to pesticides and ADHD/ADHD symptoms and 12 studies found a significant association with ASD/ASD traits. The strengths of the association and the possible confounders controlled for varied substantially across studies.
CONCLUSION
Whilst there is some evidence suggesting a possible link between pesticides and ADHD/ASD, heterogeneity across studies prevents firm conclusions. We provide methodological indications for future studies.
目的
对评估接触农药与注意力缺陷多动障碍（ADHD）或自闭症谱系障碍（ASD）之间关系的研究进行系统综述。
方法
根据在国际前瞻性系统评价注册库（PROSPERO，注册号：CRD42018107847）中预先注册的方案，我们检索了PubMed、Ovid数据库和ISI Web of Knowledge，检索时间截至2019年5月，无日期/语言/文献类型限制。采用纽卡斯尔-渥太华量表评估研究质量。
结果
在保留的29项研究中，13项聚焦于ADHD，14项聚焦于ASD，2项同时涉及这两种疾病。10项研究报告接触农药与ADHD/ADHD症状之间存在显著关联，12项研究发现与ASD/ASD特征存在显著关联。各研究中关联强度以及所控制的可能混杂因素差异很大。
结论
虽然有一些证据表明农药与ADHD/ASD之间可能存在联系，但研究之间的异质性使得无法得出确凿结论。我们为未来研究提供了方法学指导。
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