Institute for Molecular Medicine and Paul Klein Center for Immune Intervention, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
J Exp Med. 2020 Aug 3;217(8). doi: 10.1084/jem.20200574.
In this issue of JEM, Lim et al. (https://doi.org/10.1084/jem.20191810) provide exciting new evidence that talin1 plays an essential role in dendritic cell (DC) maturation and activation. Using conditional knockout mice, they demonstrate that talin1 promotes the formation of a preassembled TLR-Myddosome signaling complex in steady-state DCs but not macrophages. This may explain why DCs respond faster and more vigorously to TLR ligand binding than their closely related macrophages.
在本期《细胞- 分子生物学年鉴》中，Lim 等人（https://doi.org/10.1084/jem.20191810）提供了令人兴奋的新证据，表明 talin1 在树突状细胞（DC）成熟和激活中发挥着重要作用。他们利用条件性敲除小鼠，证明了 talin1 在静息状态的 DC 中促进预先组装的 TLR-Myddosome 信号复合物的形成，但在巨噬细胞中则不然。这或许可以解释为什么 DC 对 TLR 配体结合的反应速度比它们密切相关的巨噬细胞更快、更强。
