No information is available on the clinical use of pegaspargase during breastfeeding. Because pegaspargase is a large protein molecule with a molecular weight of about 140,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] Polyethylene glycol is not excreted into breastmilk.[3] However, the manufacturer recommends that the drug not be used during breastfeeding and for 1 month after the last dose.
关于培门冬酶在母乳喂养期间的临床应用尚无可用信息。由于培门冬酶是一种分子量约为140,000道尔顿的大蛋白质分子，乳汁中的含量可能非常低。[1]它也可能在婴儿胃肠道中被部分破坏，婴儿的吸收可能极少。[2]聚乙二醇不会排泄到母乳中。[3]然而，制造商建议在母乳喂养期间以及最后一剂后1个月内不要使用该药物。
