Taherifard Ehsan, Taherifard Erfan
Department of Medicine , Shiraz University of Medical Sciences , Shiraz, Iran.
Neurol Res. 2020 Nov;42(11):905-912. doi: 10.1080/01616412.2020.1796405. Epub 2020 Jul 23.
This study aims to systematically review the neurological complications in patients with SARS-CoV-2 infection and the methods used to diagnose both neurological complications and coronavirus infection.
Data from three different online databases (PubMed, Scopus and Web of Science) were searched on 29 April 2020 and after duplicate, irrelevant, and inappropriate records were excluded, data extraction was done.
The 22 records included for analysis provided 57 patients with neurological sequelae. The neurological complications reported ranged widely from ischemic cerebrovascular accidents to cerebral hemorrhage and were seen at both peripheral and central nervous system levels. The most frequently reported neurological complication was acute ischemic cerebrovascular accident, followed by Guillain-Barré syndrome.
Considering the possibility of neurological involvement in patients with SARS-CoV-2 infection can result in earlier diagnosis and treatment; otherwise permanent, irreversible sequelae and even death may follow. More comprehensive studies may indicate that until the end of the present pandemic, young adults with unexplained and unexpected stroke as well as patients with newly diagnosed Guillain-Barré syndrome should be tested for SARS-CoV-2 infection.
本研究旨在系统回顾2019冠状病毒病（SARS-CoV-2）感染患者的神经系统并发症以及用于诊断神经系统并发症和冠状病毒感染的方法。
于2020年4月29日在三个不同的在线数据库（PubMed、Scopus和Web of Science）中进行数据检索，排除重复、不相关和不适当的记录后进行数据提取。
纳入分析的22份记录提供了57例有神经系统后遗症的患者。报告的神经系统并发症范围广泛，从缺血性脑血管意外到脑出血，在周围神经系统和中枢神经系统层面均有出现。最常报告的神经系统并发症是急性缺血性脑血管意外，其次是吉兰-巴雷综合征。
考虑到SARS-CoV-2感染患者出现神经受累的可能性，可实现早期诊断和治疗；否则可能会导致永久性、不可逆的后遗症甚至死亡。更全面的研究可能表明，在当前大流行结束之前，原因不明和意外发生中风的年轻人以及新诊断为吉兰-巴雷综合征的患者应接受SARS-CoV-2感染检测。
