严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）与中枢神经系统。
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System.
机构信息
Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada; Department of Psychiatry, Queen's University, Kingston, ON K7L 3N6, Canada.
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil.
出版信息
Trends Neurosci. 2020 Jun;43(6):355-357. doi: 10.1016/j.tins.2020.04.004. Epub 2020 Apr 21.
Abstract
Emerging evidence indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), can cause neurological complications. We provide a brief overview of these recent observations and discuss some of their possible implications. In particular, given the global dimension of the current pandemic, we highlight the need to consider the possible long-term impact of COVID-19, potentially including neurological and neurodegenerative disorders.
摘要
新出现的证据表明，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是 2019 年冠状病毒病（COVID-19）的病原体，可引起神经系统并发症。我们简要概述了这些最新观察结果，并讨论了它们的一些可能影响。特别是，鉴于当前大流行的全球范围，我们强调需要考虑 COVID-19 可能产生的长期影响，包括潜在的神经和神经退行性疾病。
相似文献
1
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System.严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）与中枢神经系统。
Trends Neurosci. 2020 Jun;43(6):355-357. doi: 10.1016/j.tins.2020.04.004. Epub 2020 Apr 21.
2
Neurological manifestations of COVID-19: A brief review.新型冠状病毒肺炎的神经系统表现：简要综述。
Indian J Med Res. 2020;152(1 & 2):41-47. doi: 10.4103/ijmr.IJMR_1395_20.
3
Neurological complications of coronavirus and COVID-19.冠状病毒及新冠病毒病的神经系统并发症
Rev Neurol. 2020 May 1;70(9):311-322. doi: 10.33588/rn.7009.2020179.
4
[Not Available].[无可用内容]。
Rev Med Suisse. 2020 May 6;16(692):947-949.
5
[Neurological aspects of the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus].[由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病大流行的神经学方面]
Ideggyogy Sz. 2020 May 30;73(05-06):171-175. doi: 10.18071/isz.73.0171.
6
Neurological complications of COVID-19: a systematic review.新型冠状病毒肺炎的神经系统并发症：一项系统综述
Neurol Res. 2020 Nov;42(11):905-912. doi: 10.1080/01616412.2020.1796405. Epub 2020 Jul 23.
7
Role of SARS-CoV-2 neurotropism and neuroinvasion in COVID-19 patients disease severity.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的嗜神经性和神经侵袭在新冠病毒疾病（COVID-19）患者病情严重程度中的作用。
Gac Med Mex. 2020;156(4):339-343. doi: 10.24875/GMM.20000307.
8
Neuropathology of COVID-19: where are the neuropathologists?新型冠状病毒肺炎的神经病理学：神经病理学家们在哪里？
Brain Pathol. 2020 Jul;30(4):729. doi: 10.1111/bpa.12871.
9
Update on neurological manifestations of COVID-19.关于 COVID-19 的神经系统表现的最新消息。
Life Sci. 2020 Sep 15;257:118063. doi: 10.1016/j.lfs.2020.118063. Epub 2020 Jul 9.
10
Sars-Cov-2: Underestimated damage to nervous system.严重急性呼吸综合征冠状病毒2：对神经系统的损害被低估
Travel Med Infect Dis. 2020 Jul-Aug;36:101642. doi: 10.1016/j.tmaid.2020.101642. Epub 2020 Mar 24.
引用本文的文献
1
Comparison of cerebrospinal fluid biomarkers in patients with severe COVID-19 neurological outcomes and Alzheimer's disease.患有严重新冠病毒病神经学结局的患者与阿尔茨海默病患者脑脊液生物标志物的比较。
Brain Behav Immun Health. 2025 Apr 30;46:101007. doi: 10.1016/j.bbih.2025.101007. eCollection 2025 Jul.
2
Factors Influencing Physical Performance and Quality of Life in Post-COVID-19 Patients.影响新冠康复患者身体机能和生活质量的因素
Diseases. 2025 Apr 19;13(4):120. doi: 10.3390/diseases13040120.
3
Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications.神经炎症生物标志物的变化与新冠病毒病（COVID-19）神经系统并发症患者的疾病严重程度及神经影像学改变相关。
Brain Behav Immun Health. 2024 Jun 13;39:100805. doi: 10.1016/j.bbih.2024.100805. eCollection 2024 Aug.
4
SARS-CoV-2 Nucleocapsid Protein Induces Tau Pathological Changes That Can Be Counteracted by SUMO2.SARS-CoV-2 核衣壳蛋白诱导 tau 病理变化，这种变化可以被 SUMO2 抵消。
Int J Mol Sci. 2024 Jun 28;25(13):7169. doi: 10.3390/ijms25137169.
5
Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects.SARS-CoV-2 的宿主因素在感染、发病机制和长期影响中的作用。
Front Cell Infect Microbiol. 2024 May 22;14:1407261. doi: 10.3389/fcimb.2024.1407261. eCollection 2024.
6
Cognitive dysfunctions in the course of SARS‑CoV‑2 virus infection, including NeuroCOVID, frontal syndrome and cytokine storm (Review).严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染过程中的认知功能障碍，包括神经型冠状病毒病、额叶综合征和细胞因子风暴（综述）
Biomed Rep. 2024 May 16;21(1):103. doi: 10.3892/br.2024.1791. eCollection 2024 Jul.
7
Risk perception of patients with chronic illnesses toward the SARS-CoV-2 in northeastern Ethiopia in 2020.2020年埃塞俄比亚东北部慢性病患者对新冠病毒的风险认知
Prev Med Rep. 2024 May 9;43:102751. doi: 10.1016/j.pmedr.2024.102751. eCollection 2024 Jul.
8
A Narrative Review on the Clinical Relevance of Imaging the Circumventricular Brain Organs and Performing Their Anatomical and Histopathological Examination in Acute and Postacute COVID-19.关于在急性和亚急性 COVID-19 中对脑周围器官进行影像学检查和进行解剖及组织病理学检查的临床相关性的叙述性综述。
Am J Forensic Med Pathol. 2024 Jun 1;45(2):151-156. doi: 10.1097/PAF.0000000000000939.
9
(African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines.（非洲星苹果）水果补充饮食可增强认知功能，并减轻脂多糖诱导的记忆损伤、氧化应激和促炎细胞因子的释放。
Nutrire. 2020;45(2):20. doi: 10.1186/s41110-020-00123-3. Epub 2020 Aug 26.
10
Investigating the structural network underlying brain-immune interactions using combined histopathology and neuroimaging: a critical review for its relevance in acute and long COVID-19.运用组织病理学与神经影像学相结合的方法研究脑-免疫相互作用的结构网络：对其在急性和长期新冠病毒感染中的相关性的批判性综述
Front Psychiatry. 2024 Mar 25;15:1337888. doi: 10.3389/fpsyt.2024.1337888. eCollection 2024.
本文引用的文献
1
Neurologic Features in Severe SARS-CoV-2 Infection.严重SARS-CoV-2感染的神经系统特征
N Engl J Med. 2020 Jun 4;382(23):2268-2270. doi: 10.1056/NEJMc2008597. Epub 2020 Apr 15.
2
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.中国武汉住院的 2019 年冠状病毒病患者的神经系统表现。
JAMA Neurol. 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127.
3
Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?COVID-19 感染中的孤立性突发性嗅觉丧失。一种新综合征？
Rhinology. 2020 Jun 1;58(3):299-301. doi: 10.4193/Rhin20.114.
4
COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features.新型冠状病毒肺炎相关急性出血性坏死性脑病：影像学特征
Radiology. 2020 Aug;296(2):E119-E120. doi: 10.1148/radiol.2020201187. Epub 2020 Mar 31.
5
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.113 例新冠肺炎死亡患者的临床特征：回顾性研究。
BMJ. 2020 Mar 26;368:m1091. doi: 10.1136/bmj.m1091.
6
Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis.Th17 淋巴细胞在感染后自身免疫性脑炎的小鼠模型中导致血管和神经缺陷。
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6708-6716. doi: 10.1073/pnas.1911097117. Epub 2020 Mar 11.
7
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.中国武汉严重 COVID-19 患者的临床病程和结局：一项单中心、回顾性、观察性研究。
Lancet Respir Med. 2020 May;8(5):475-481. doi: 10.1016/S2213-2600(20)30079-5. Epub 2020 Feb 24.
8
Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child.免疫功能低下儿童感染冠状病毒 OC43 导致的致命脑炎。
Infect Dis (Lond). 2020 Jun;52(6):419-422. doi: 10.1080/23744235.2020.1729403. Epub 2020 Feb 18.
9
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?人类冠状病毒和其他呼吸道病毒：被低估的中枢神经系统机会性病原体？
Viruses. 2019 Dec 20;12(1):14. doi: 10.3390/v12010014.
10
Mechanisms of Pathogen Invasion into the Central Nervous System.病原体入侵中枢神经系统的机制。
Neuron. 2019 Sep 4;103(5):771-783. doi: 10.1016/j.neuron.2019.07.015.
Zotero 插件