State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, China.
Br J Ophthalmol. 2021 Jul;105(7):970-976. doi: 10.1136/bjophthalmol-2020-315852. Epub 2020 Jul 22.
To assess the association of anterior segment optical coherence tomography (AS-OCT) parameters and 5-year incident narrow angle in China.
This was a prospective cohort study of people aged 50 and older residing in Liwan District, Guangzhou, China. Random clustering sampling was used to identify adults aged 50 years and older in Liwan District, Guangzhou. In 2008 and 2013, this study was repeated and added AS-OCT imaging under dark and light conditions. Customised software (ZAAP) was used to analyse horizontal AS-OCT scans. Angle opening distance (AOD), trabecular iris space area (TISA), anterior chamber volume (ACV) and maximal iris thickness (ITM) were measured. Multiple logistic regression analysis models were used to investigate the associations of the final angle status with baseline AS-OCT parameters. ORs and 95% CIs were calculated.
Of the 220 subjects with eligible AS-OCT images and gonioscopic results in 2008, the response rate was 77.3%. A total of 27 (15.9%) subjects developed narrow angles and 143 (84.1%) had open angles on gonioscopy in 2013. Subjects developed narrow angles had greater spherical equivalent and shallower anterior chamber depth, smaller angle parameters, thicker IT750 and ITM, smaller anterior chamber parameters, greater lens vault, and smaller dynamic parameters (ΔITM, ΔACA, ΔACV) at baseline. After adjusting confounders, the predictors of incident narrow angles included smaller AOD750, TISA750, ΔACA and greater ITM, ΔIarea.
Incident narrow angles were associated with smaller anterior ocular dimensions, thicker iris and smaller light-to-dark changes at baseline. These findings can help in early diagnosis in this population.
评估中国眼前节光学相干断层扫描（AS-OCT）参数与 5 年发生窄角的相关性。
这是一项在中国广州荔湾区进行的前瞻性队列研究。采用随机聚类抽样方法，在广州荔湾区识别出 50 岁及以上的成年人。2008 年和 2013 年，本研究再次进行，并在暗光和亮光条件下增加了 AS-OCT 成像。使用定制软件（ZAAP）分析水平 AS-OCT 扫描。测量房角开口距离（AOD）、小梁虹膜空间面积（TISA）、前房容积（ACV）和最大虹膜厚度（ITM）。采用多因素逻辑回归分析模型，探讨最终角状态与基线 AS-OCT 参数的相关性。计算比值比（OR）及其 95%置信区间（CI）。
在 2008 年具有合格 AS-OCT 图像和房角镜结果的 220 名受试者中，应答率为 77.3%。2013 年，共有 27 名（15.9%）受试者发生窄角，143 名（84.1%）受试者发生开角。发生窄角的受试者具有更大的等效球镜度数和更浅的前房深度、更小的角参数、更厚的 IT750 和 ITM、更小的前房参数、更大的晶状体拱顶和更小的动态参数（ΔITM、ΔACA、ΔACV）。在调整混杂因素后，发生窄角的预测因子包括更小的 AOD750、TISA750、ΔACA 和更大的 ITM、ΔIarea。
发生窄角与更小的眼前节尺寸、更厚的虹膜和更大的暗光到亮光变化有关。这些发现有助于该人群的早期诊断。
