Kim Yaerim, Lee Soojin, Lee Yeonhee, Kang Min Woo, Park Sehoon, Park Sanghyun, Han Kyungdo, Paek Jin Hyuk, Park Woo Yeong, Jin Kyubok, Han Seungyeup, Han Seung Seok, Lee Hajeong, Lee Jung Pyo, Joo Kwon Wook, Lim Chun Soo, Kim Yon Su, Kim Dong Ki
Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Keimyung University Kidney Institute, Daegu, Korea.
Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):2070-2077. doi: 10.1158/1055-9965.EPI-20-0078. Epub 2020 Jul 22.
Glomerular hyperfiltration is associated with all-cause mortality. Herein, we evaluated the association between glomerular hyperfiltration and the development of cancer, the most common cause of death, in an Asian population.
We retrospectively reviewed the National Health Insurance Service database of Korea for people who received national health screenings from 2012 to 2013. Glomerular hyperfiltration was defined as the 95th percentile and greater after stratification by sex and age decile. We performed a multivariate Cox regression analysis using glomerular hyperfiltration at the first health screening as the exposure variable and cancer development as the outcome variable to evaluate the impact of glomerular hyperfiltration on the development of cancer.
A total of 1,953,123 examinations for patients with a median follow-up time of 4.4 years were included in this study. Among the 8 different site-specific cancer categories, digestive organs showed significant associations between glomerular hyperfiltration and cancer. The population with glomerular hyperfiltration showed an increased risk for stomach cancer [adjusted hazard ratio (aHR) = 1.22], colorectal cancer (aHR = 1.16), and liver or intrahepatic malignancy (aHR = 1.35).
Glomerular hyperfiltration was associated with an increased risk for the development of cancer in specific organs, such as the stomach, colorectum, and liver and intrahepatic organ.
Glomerular hyperfiltration needs to be considered a significant sign of the need to evaluate the possibility of hidden adverse health conditions, including malignancies.
肾小球高滤过与全因死亡率相关。在此，我们评估了亚洲人群中肾小球高滤过与癌症（最常见的死亡原因）发生之间的关联。
我们回顾性研究了韩国国民健康保险服务数据库中2012年至2013年接受国民健康筛查的人群。肾小球高滤过定义为按性别和年龄十分位数分层后处于第95百分位数及以上。我们以首次健康筛查时的肾小球高滤过作为暴露变量，癌症发生作为结局变量进行多因素Cox回归分析，以评估肾小球高滤过对癌症发生的影响。
本研究共纳入1,953,123例检查，患者中位随访时间为4.4年。在8种不同部位特异性癌症类别中，消化器官显示出肾小球高滤过与癌症之间存在显著关联。肾小球高滤过人群患胃癌[调整后风险比（aHR）= 1.22]、结直肠癌（aHR = 1.16）以及肝脏或肝内恶性肿瘤（aHR = 1.35）的风险增加。
肾小球高滤过与特定器官（如胃、结肠直肠、肝脏及肝内器官）癌症发生风险增加相关。
肾小球高滤过需要被视为评估包括恶性肿瘤在内的潜在不良健康状况可能性的一个重要指标。
