McCall Micaela V, Riva-Posse Patricio, Garlow Steven J, Mayberg Helen S, Crowell Andrea L
Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences.
University of Wisconsin School of Medicine and Public Health.
Neurol Psychiatry Brain Res. 2020 Sep;37:33-40. doi: 10.1016/j.npbr.2020.05.002. Epub 2020 Jun 11.
Traditional rating scales for depression rely heavily on patient self-report, and lack detailed measurement of non-verbal behavior. However, there is evidence that depression is associated with distinct non-verbal behaviors, assessment of which may provide useful information about recovery. This study examines non-verbal behavior in a sample of patients receiving Deep Brain Stimulation (DBS) treatment of depression, with the purpose to investigate the relationship between non-verbal behaviors and reported symptom severity.
Videotaped clinical interviews of twelve patients participating in a study of DBS for treatment-resistant depression were analyzed at three time points (before treatment and after 3 months and 6 months of treatment), using an ethogram to assess the frequencies of 42 non-verbal behaviors. The Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS-17) were also collected at all time points.
Factor analysis grouped non-verbal behaviors into three factors: , and . Two-way repeated measures ANOVA showed that scores on the three factors change differently from each other over time. Mixed effects modelling assessed the relationship between BDI score and frequency of non-verbal behaviors, and provided evidence that the frequency of behaviors related to reactivity and engagement increase as BDI score decreases.
This study assesses a narrow sample of patients with a distinct clinical profile at limited time points.
Non-verbal behavior provides information about clinical states and may be reliably quantified using ethograms. Non-verbal behavior may provide distinct information compared to self-report.
传统的抑郁评定量表严重依赖患者的自我报告，且缺乏对非言语行为的详细测量。然而，有证据表明抑郁与独特的非言语行为有关，对其进行评估可能会提供有关康复的有用信息。本研究对接受深部脑刺激（DBS）治疗抑郁症的患者样本中的非言语行为进行了研究，目的是调查非言语行为与报告的症状严重程度之间的关系。
对12名参与DBS治疗难治性抑郁症研究的患者的临床访谈录像在三个时间点（治疗前、治疗3个月后和6个月后）进行分析，使用行为图谱评估42种非言语行为的频率。在所有时间点还收集了贝克抑郁量表（BDI）和汉密尔顿抑郁评定量表（HDRS - 17）。
因子分析将非言语行为分为三个因子：……。双向重复测量方差分析表明，这三个因子的得分随时间变化各不相同。混合效应模型评估了BDI得分与非言语行为频率之间的关系，并提供证据表明，随着BDI得分降低，与反应性和参与度相关的行为频率增加。
本研究在有限的时间点评估了具有独特临床特征的狭窄患者样本。
非言语行为提供了有关临床状态的信息，并且可以使用行为图谱进行可靠的量化。与自我报告相比，非言语行为可能提供不同的信息。
