Loo Steven King-Fan, Hon Kam Lun, Leung Alexander Kc, Yung Tak Cheung, Yam Man Ching
The Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong.
Department of Paediatrics & The Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong.
Drugs Context. 2020 Jul 7;9. doi: 10.7573/dic.2020-4-1. eCollection 2020.
We have managed two anonymized siblings with Kawasaki disease (KD). The occurrence of KD in the elder brother alerted us to the occurrence of incomplete KD in the younger brother. Both siblings were treated with intravenous immunoglobulin and a high dose of dipyridamole with resolution of the coronary artery aneurysm. Dipyridamole was used instead of aspirin because both siblings were glucose-6-phosphate dehydrogenase deficient for which aspirin was contraindicated. To prevent damage to the coronary arteries, treatment should be started as soon as the diagnosis is made. There have been a lot of advances in medical therapy in recent years, which are reviewed together with conventional proven therapy for KD. Early diagnosis and prompt treatment are important to achieve optimal treatment outcome in KD. Family history of KD among siblings enables clinicians for an earlier diagnosis so as to prevent the disease complications particularly in patients with incomplete features.
我们诊治了两名患川崎病（KD）的匿名同胞兄弟。哥哥患KD促使我们留意到弟弟可能患不完全KD。兄弟俩均接受了静脉注射免疫球蛋白和高剂量双嘧达莫治疗，冠状动脉瘤消退。因兄弟俩均缺乏葡萄糖-6-磷酸脱氢酶，阿司匹林为禁忌药，故使用双嘧达莫替代阿司匹林。为预防冠状动脉受损，一旦确诊应立即开始治疗。近年来医学治疗有了很大进展，本文将其与KD的传统有效疗法一同进行综述。早期诊断和及时治疗对于KD取得最佳治疗效果很重要。同胞兄弟中有KD家族史可使临床医生更早诊断，从而预防疾病并发症，尤其是对于具有不完全特征的患者。
