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[严重急性呼吸综合征冠状病毒2的特征及潜在药物治疗]

[Characteristics of SARS-CoV-2 and potential pharmacological treatment].

作者信息

Pawlik Leon, Śpiołek Emilian, Fichna Jakub, Tarasiuk Aleksandra

机构信息

Zakład Biochemii, Katedra Chemii i Biochemii Medycznej, Uniwersytet Medyczny w Łodzi.

出版信息

Postepy Biochem. 2020 May 9;66(2):83-90. doi: 10.18388/pb.2020_321.

Abstract

In December 2019 in Wuhan, China the first cases of previously unknown, coronaviral infection-induced pneumonia have been reported. The new virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) was named after SARS-CoV due to their similarities and the disease caused by the pathogen is COVID-19 (Coronavirus Disease 2019). On 11 March 2020 WHO (World Health Organization) defined the rapidly increasing number of incidents of COVID-19 as a pandemic. In this review we will present recent information about the SARS-CoV-2 focusing on the origin, clinical picture, diagnostic methods, structure, replication cycle of SARS-CoV-2 and potential pharmaceutical measures against COVID-19.

摘要

2019年12月,中国武汉报告了首例此前未知的由冠状病毒感染引起的肺炎病例。新型病毒SARS-CoV-2(严重急性呼吸综合征冠状病毒2)因其与SARS-CoV相似而得名,该病原体引起的疾病是COVID-19(2019冠状病毒病)。2020年3月11日,世界卫生组织(WHO)将迅速增加的COVID-19事件定义为大流行病。在这篇综述中,我们将介绍关于SARS-CoV-2的最新信息,重点关注SARS-CoV-2的起源、临床表现、诊断方法、结构、复制周期以及针对COVID-19的潜在药物措施。

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