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粪便中可检测到 SARS-CoV-2 病毒 RNA 于 COVID-19 肺炎恢复期的 3 名儿童。

Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia.

机构信息

Department of Respiratory, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.

Graduate School of Tianjin Medical University, Tianjin, China.

出版信息

J Med Virol. 2020 Jul;92(7):909-914. doi: 10.1002/jmv.25795. Epub 2020 Apr 15.

Abstract

Coronavirus Disease 2019 (COVID-19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After its first occurrence in Wuhan of China from December 2019, COVID-19 rapidly spread around the world. According to the World Health Organization statement on 13 March 2020, there had been over 132 500 confirmed cases globally. Nevertheless, the case reports of children are rare, which results in the lack of evidence for preventing and controlling of children's infection. Here, we report three cases of SARS-CoV-2 infected children diagnosed from 3 February to 17 February 2020 in Tianjin, China. All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. However, after been discharged, all three cases were tested SARS-CoV-2 positive in the stool samples within 10 days, in spite of their remained negative nucleic acid in throat swab specimens. Therefore, it is necessary to be aware of the possibility of fecal-oral transmission of SARS-CoV-2 infection, especially for children cases.

摘要

新型冠状病毒病(COVID-19)是一种由新型冠状病毒,即严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引起的新发传染病。自 2019 年 12 月在中国武汉首次出现以来,COVID-19 迅速在全球范围内传播。根据世界卫生组织 2020 年 3 月 13 日的声明,全球已确诊超过 132500 例病例。然而,儿童病例报告罕见,这导致缺乏儿童感染的预防和控制证据。在这里,我们报告了 3 例于 2020 年 2 月 3 日至 2 月 17 日在中国天津确诊的 SARS-CoV-2 感染儿童病例。这 3 例病例均为轻症,经治疗后很快康复,咽拭子核酸分别在诊断后 14、11 和 7 天转为阴性。然而,出院后,这 3 例患儿的粪便样本中仍在 10 天内检测到 SARS-CoV-2 阳性,尽管咽拭子标本中仍为核酸阴性。因此,有必要意识到 SARS-CoV-2 感染存在粪-口传播的可能性,特别是对儿童病例。

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[First case of severe childhood novel coronavirus pneumonia in China].[中国首例儿童重症新型冠状病毒肺炎病例]
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