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[增加炎症性肠病激活和发展风险的环境因素]

[Environmental factors increasing the risk of activation and development of inflammatory bowel diseases].

作者信息

Mrowicki Jerzy, Mrowicka Małgorzata, Majsterek Ireneusz

机构信息

Zakład Chemii i Biochemii Klinicznej, Uniwersytet Medyczny w Łodzi, Narutowicza 60, Łódź 90-136.

出版信息

Postepy Biochem. 2020 Jun 27;66(2):167-175. doi: 10.18388/pb.2020_318.

Abstract

Inflammatory bowel disease (IBD) is a particularly troublesome disease that has a huge impact on the human digestive tract, mainly the intestine. These diseases manifest themselves as chronic, uncontrolled inflammation of the intestines, difficult to control, with periods of spontaneous exacerbations and remissions. Depending on the variety of symptoms present and their location in the human gastrointestinal tract, these diseases can occur in various forms. The most common: ulcerative colitis (UC) and Crohn’s disease (CD). The underlying cause of activation as well as subsequent development is not clearly defined, but it is known that these disorders are autoimmune. The pathogenesis of IBD is associated with chronic idiopathic, recurrent gastrointestinal inflammation. Exposure to many environmental factors, which are partially discussed in the following work, especially in people genetically predisposed to the development of these diseases, can activate the chronic inflammatory process of the intestine.

摘要

炎症性肠病(IBD)是一种特别棘手的疾病,对人体消化道,主要是肠道有巨大影响。这些疾病表现为肠道的慢性、无法控制的炎症,难以控制,会有自发加重和缓解期。根据出现的各种症状及其在人体胃肠道中的位置,这些疾病可以有多种形式。最常见的是:溃疡性结肠炎(UC)和克罗恩病(CD)。激活以及后续发展的根本原因尚未明确界定,但已知这些病症是自身免疫性的。IBD的发病机制与慢性特发性复发性胃肠道炎症有关。接触许多环境因素,以下文章将部分进行讨论,尤其是在有这些疾病遗传易感性的人群中,可激活肠道的慢性炎症过程。

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