Medical Imaging Department, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, P.R. China.
Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Nutr Cancer. 2021;73(8):1371-1377. doi: 10.1080/01635581.2020.1795211. Epub 2020 Jul 22.
The higher level of background parenchymal enhancement (BPE) at breast magnetic resonance imaging (MRI) has drawn considerable attention in the early detection and prediction of breast cancer. It has been reported that there is a possible relationship between the level of BPE at breast MRI and the presence of breast cancer. This meta-analysis was performed to evaluate this relationship.
Through a systematic literature search up to December 2019, 12 studies with 9541 females, 3870 of them were breast cancer. They were identified reporting relationships between breast cancer and BPE at breast MRI with its different categories (10 related to minimal or mild BPE, eight related to moderate BPE and nine related to high BPE). Odd ratio(OR) with 95% confidence intervals (CIs) was calculated comparing breast cancer prevalence and BPE at breast MRI using dichotomous method with a random or fixed effect model.
Females with high (OR, 2.93; 95% CI, 1.24-6.88) and moderate (OR, 2.89; 95% CI, 1.51-5.52) BPE at breast MRI was related with high odds to breast cancer compared to control females. However, females with minimal or mild BPE at breast MRI (OR, 1.33; 95% CI, 0.56-3.17) did not have such risk on breast cancer. The impact of BPE on breast cancer may have a great influence as a tool for improving early detection and prevention of breast cancer.
Based on this meta-analysis, females with high or moderate BPE at breast MRI may have an independent relationship with the risk of breast cancer. This relationship forces us to recommend follow up with those with high or moderate BPE at breast MRI to avoid any complication.
乳腺磁共振成像（MRI）中的背景实质强化（BPE）水平较高引起了人们对乳腺癌早期检测和预测的极大关注。据报道，乳腺 MRI 中 BPE 水平与乳腺癌的存在之间可能存在一定的关系。进行这项荟萃分析是为了评估这种关系。
通过系统的文献搜索，截至 2019 年 12 月，共纳入 12 项研究，涉及 9541 名女性，其中 3870 名为乳腺癌患者。这些研究报告了乳腺癌与乳腺 MRI 中 BPE 及其不同分类之间的关系（10 项研究与轻度或轻度 BPE 相关，8 项研究与中度 BPE 相关，9 项研究与高度 BPE 相关）。使用二项式方法，以随机或固定效应模型，计算乳腺癌患病率和乳腺 MRI 中 BPE 之间的比值比（OR）及其 95%置信区间（CI）。
与对照组女性相比，乳腺 MRI 中 BPE 水平较高（OR，2.93；95%CI，1.24-6.88）和中度（OR，2.89；95%CI，1.51-5.52）的女性发生乳腺癌的可能性更高。然而，乳腺 MRI 中 BPE 水平轻度或轻度（OR，1.33；95%CI，0.56-3.17）的女性患乳腺癌的风险没有增加。BPE 对乳腺癌的影响可能作为提高乳腺癌早期检测和预防的工具具有重要意义。
基于这项荟萃分析，乳腺 MRI 中 BPE 水平较高或中度的女性可能与乳腺癌风险有独立的关系。这种关系迫使我们建议对乳腺 MRI 中 BPE 水平较高或中度的女性进行随访，以避免任何并发症。
