Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine , Seoul, Republic of Korea.
Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine , Seoul, Republic of Korea.
Expert Opin Drug Saf. 2020 Oct;19(10):1349-1356. doi: 10.1080/14740338.2020.1796965. Epub 2020 Aug 18.
The human leukocyte antigen (HLA)-B*13:01 was reported as an important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and Thai populations.
From the Korean nationwide registry, seven subjects with previous DHS were included. Their HLA allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects recruited from a single institution, and general population (n = 485) in Korea. The authors also performed a meta-analysis with these data using previous Chinese and Thai studies.
Among the seven DHS subjects, 85.7% presented with the HLA-B13:01 allele. The HLA-C03:04, HLA-DRB112:02 (both in linkage disequilibrium with HLA-B13:01), and HLA-A02:01 alleles were also presented in 85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B13:01 were susceptible to developing DHS compared to dapsone-tolerant controls (odds ratio [OR]: 73.667) and the Korean general population (OR: 139.500). HLA-C03:04 (OR: 40.935), HLA-DRB12:02 (OR: 36.613), and HLA-A02:01 (OR: 5.862) showed similar results. In meta-analysis, HLA-B13:01 was associated with dapsone-induced hypersensitivity (overall OR: 42.692), and subgroup analyses according to the control types demonstrated similar results (OR:43.694 and 41.866, respectively).
Similar to previous Asian population studies, HLA-B*13:01 is significantly associated with the risk of DHS in Korea. These associations may be useful for preventing DHS and improving drug safety.
人类白细胞抗原（HLA）-B*13:01 已被报道为中泰人群中导致氨苯砜超敏综合征（DHS）的重要危险因素。
从韩国全国登记处纳入 7 例既往有 DHS 的患者。比较他们的 HLA 等位基因/表型频率与从一家机构招募的 8 例氨苯砜耐受患者以及韩国的一般人群（n=485）。作者还使用先前的中国和泰国研究数据进行了荟萃分析。
在 7 例 DHS 患者中，85.7%存在 HLA-B13:01 等位基因。HLA-C03:04、HLA-DRB112:02（均与 HLA-B13:01 连锁不平衡）和 HLA-A02:01 等位基因也分别在 85.7%、71.4%和 71.4%的患者中出现。与氨苯砜耐受对照（比值比[OR]：73.667）和韩国一般人群（OR：139.500）相比，携带 HLA-B13:01 的患者更易发生 DHS。HLA-C03:04（OR：40.935）、HLA-DRB12:02（OR：36.613）和 HLA-A02:01（OR：5.862）也有类似结果。荟萃分析显示，HLA-B13:01 与氨苯砜诱导的超敏反应相关（总体 OR：42.692），根据对照类型的亚组分析也得出了类似结果（OR：43.694 和 41.866）。
与先前的亚洲人群研究相似，HLA-B*13:01 与韩国 DHS 的风险显著相关。这些关联可能有助于预防 DHS 和提高药物安全性。
