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微小 RNA 靶向 Wnt/β-连环蛋白信号通路调控癌症中的上皮-间充质转化（综述）。

MicroRNAs target the Wnt/β‑catenin signaling pathway to regulate epithelial‑mesenchymal transition in cancer (Review).

机构信息

Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, P.R. China.

Department of Big Data Research of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China.

出版信息

Oncol Rep. 2020 Oct;44(4):1299-1313. doi: 10.3892/or.2020.7703. Epub 2020 Jul 23.

DOI:10.3892/or.2020.7703
PMID:32700744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7448411/
Abstract

Epithelial‑mesenchymal transition (EMT), during which cancer cells lose the epithelial phenotype and gain the mesenchymal phenotype, has been verified to result in tumor migration and invasion. Numerous studies have shown that dysregulation of the Wnt/β‑catenin signaling pathway gives rise to EMT, which is characterized by nuclear translocation of β‑catenin and E‑cadherin suppression. Wnt/β‑catenin signaling was confirmed to be affected by microRNAs (miRNAs), several of which are down‑ or upregulated in metastatic cancer cells, indicating their complex roles in Wnt/β‑catenin signaling. In this review, we demonstrated the targets of various miRNAs in altering Wnt/β‑catenin signaling to promote or inhibit EMT, which may elucidate the underlying mechanism of EMT regulation by miRNAs and provide evidence for potential therapeutic targets in the treatment of invasive tumors.

摘要

上皮-间充质转化（EMT），在此过程中癌细胞失去上皮表型并获得间充质表型，已被证实可导致肿瘤迁移和侵袭。许多研究表明，Wnt/β-连环蛋白信号通路的失调导致 EMT，其特征是β-连环蛋白和 E-钙粘蛋白的核转位抑制。已经证实 Wnt/β-连环蛋白信号受 microRNAs（miRNAs）的影响，其中一些在转移性癌细胞中下调或上调，表明它们在 Wnt/β-连环蛋白信号中具有复杂的作用。在这篇综述中，我们展示了各种 miRNAs 在改变 Wnt/β-连环蛋白信号以促进或抑制 EMT 中的靶标，这可能阐明 miRNA 调节 EMT 的潜在机制，并为侵袭性肿瘤治疗提供潜在治疗靶点的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/7448411/a61726f6122a/OR-44-04-1299-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/7448411/edeb47fe94d0/OR-44-04-1299-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/7448411/a61726f6122a/OR-44-04-1299-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/7448411/edeb47fe94d0/OR-44-04-1299-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/7448411/a61726f6122a/OR-44-04-1299-g01.jpg

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