Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of York, Heslington, UK.
Chem Soc Rev. 2020 Sep 7;49(17):6169-6185. doi: 10.1039/c9cs00840c. Epub 2020 Jul 23.
Yttrium is a chemically versatile rare earth element that finds use in a range of applications including lasers and superconductors. In medicine, yttrium-based materials are used in medical lasers and biomedical implants. This is extended through the array of available yttrium isotopes to enable roles for Y complexes as radiopharmaceuticals and Y tracers for positron emission tomography (PET) imaging. The naturally abundant isotope Y is proving to be suitable for nuclear magnetic resonance investigations, where initial reports in the emerging field of hyperpolarised magnetic resonance imaging (MRI) are promising. In this review we explore the coordination and radiochemical properties of yttrium, and its role in drugs for radiotherapy, PET imaging agents and perspectives for applications in hyperpolarised MRI.
钇是一种化学性质多样的稀土元素，在包括激光和超导在内的一系列应用中都有使用。在医学领域，基于钇的材料被用于医学激光和生物医学植入物。通过提供各种可用的钇同位素，钇配合物可用作放射性药物和正电子发射断层扫描（PET）成像的示踪剂。天然丰富的同位素 Y 被证明适用于磁共振研究，在新兴的超极化磁共振成像（MRI）领域的初步报告很有前景。在这篇综述中，我们探讨了钇的配位和放射化学性质，以及它在放射治疗药物、PET 成像剂中的作用，以及在超极化 MRI 中的应用前景。
