Skidmore Jeffrey, He Shuman
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Department of Audiology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Ear Hear. 2021 Jan/Feb;42(1):244-247. doi: 10.1097/AUD.0000000000000919.
This study reports two potential biomarkers of the physiological status of the cochlear nerve (CN) in cochlear implant users.
This project represents a complementary analysis on a subset of electrophysiological data from our recently published study. This study compared changes in N1 latency and stimulation level (i.e., N1 latency offset and stimulation level offset) with increasing interphase gap of a biphasic pulse between children with cochlear nerve deficiency and children with normal-sized CNs.
Children with cochlear nerve deficiency showed smaller N1 latency offsets and larger stimulation level offsets than children with normal-sized CNs at all electrode locations tested.
The N1 latency and stimulation level offsets differ in two patient populations with different physiological statuses of the CN. These parameters may be useful for evaluating CN function in individual cochlear implant patients.
本研究报告了人工耳蜗使用者蜗神经（CN）生理状态的两种潜在生物标志物。
本项目是对我们最近发表的研究中的一部分电生理数据进行的补充分析。本研究比较了蜗神经缺损儿童和蜗神经正常大小儿童在双相脉冲相间间隙增加时N1潜伏期和刺激水平（即N1潜伏期偏移和刺激水平偏移）的变化。
在所有测试电极位置，蜗神经缺损儿童的N1潜伏期偏移较小，刺激水平偏移较大，而蜗神经正常大小的儿童则相反。
N1潜伏期和刺激水平偏移在蜗神经生理状态不同的两组患者中存在差异。这些参数可能有助于评估个体人工耳蜗植入患者的蜗神经功能。
