Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Lab Med. 2021 Jan 4;52(1):57-63. doi: 10.1093/labmed/lmaa042.
This study aimed to clarify the distribution characteristics of serum pepsinogen (PG) and Helicobacter pylori in the medical examination population and to explore the relationships of PG level and H. pylori infection status with the high-sensitivity C-reactive protein (hsCRP) level and their significance in health examination.
We detected H. pylori infection by C13 urea breath test, the serum pepsinogen I (PGI) and pepsinogen II (PGII) contents were measured by chemiluminescence microparticle immunoassay, and the PGI/PGII ratio was calculated. In addition, the serum hsCRP level was determined by the Abbott C16000 automatic biochemical analyzer.
The PGI and hsCRP levels were significantly higher in men than in women, and the PGII level was slightly higher in men than in women (both P <.05). The PGI, PGII, and hsCRP levels were positively correlated with age (r = 0.210, 0.287, and 0.133, respectively; P <.05), whereas the PGI/PGII ratio was negatively correlated with age (r = -0.190; P <.05). The positive H. pylori infection rate was 30.2% among the patients in this study; H. pylori infection was not related to sex (P >.05), and the difference in age stratification was not statistically significant (P >.05). The abnormal PGI/PGII ratio in the medical examination population was not correlated with sex (P >.05). In the H. pylori positive infection group, the proportion of PGI/PGII ratio <3, the PGI and PGII levels were significantly higher than those in the H. pylori negative infection group, and the PGI/PGII ratio was significantly lower than that in the negative group (both P <.05). The hsCRP level was not associated with H. pylori infection (P >.05), and it was significantly higher in the PGI/PGII ratio <3 group than in the PGI/PGII ratio ≥3 group (P <.05).
The PGI and PGII levels and the PGI/PGII ratio are correlated with H. pylori infection. The abnormal PGI/PGII ratio is closely related to H. pylori infection and hsCRP level. Therefore, H. pylori infection status and hsCRP level should be considered when determining atrophic gastritis by the PGI/PGII ratio.
本研究旨在阐明体检人群血清胃蛋白酶原（PG）和幽门螺杆菌的分布特征，并探讨 PG 水平和 H. pylori 感染状态与高敏 C 反应蛋白（hsCRP）水平的关系及其在健康体检中的意义。
采用 C13 尿素呼气试验检测 H. pylori 感染，化学发光微粒子免疫检测法检测血清胃蛋白酶原 I（PGI）和胃蛋白酶原 II（PGII）含量，计算 PGI/PGII 比值。同时采用雅培 C16000 全自动生化分析仪检测血清 hsCRP 水平。
男性的 PGI 和 hsCRP 水平明显高于女性，PGII 水平略高于女性（均 P <.05）。PGI、PGII 和 hsCRP 水平与年龄呈正相关（r = 0.210、0.287 和 0.133，均 P <.05），而 PGI/PGII 比值与年龄呈负相关（r = -0.190；P <.05）。本研究患者的 H. pylori 阳性感染率为 30.2%；H. pylori 感染与性别无关（P >.05），年龄分层差异无统计学意义（P >.05）。体检人群异常的 PGI/PGII 比值与性别无关（P >.05）。在 H. pylori 阳性感染组中，PGI/PGII 比值<3 的比例、PGI 和 PGII 水平明显高于 H. pylori 阴性感染组，PGI/PGII 比值明显低于阴性组（均 P <.05）。hsCRP 水平与 H. pylori 感染无关（P >.05），PGI/PGII 比值<3 组明显高于 PGI/PGII 比值≥3 组（P <.05）。
PGI、PGII 水平和 PGI/PGII 比值与 H. pylori 感染相关。异常的 PGI/PGII 比值与 H. pylori 感染和 hsCRP 水平密切相关。因此，在通过 PGI/PGII 比值判断萎缩性胃炎时，应考虑 H. pylori 感染状态和 hsCRP 水平。
