Department of Gerontology and Geriatrics, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
World J Gastroenterol. 2017 Aug 28;23(32):5945-5953. doi: 10.3748/wjg.v23.i32.5945.
To observe changes in gastric biomarker levels with age and effects of () infection in a healthy population, and explore factors associated with gastric biomarkers.
Three hundred and ninety-five subjects were selected and underwent physical examinations, biochemical tests, and measurement of serum pepsinogen (PG) I and II, gastrin-17 (G-17) and antibody levels. Analyses were made by Student's -test, ANOVA, Pearson's correlation and multiple linear regressions.
PGII levels were higher in the ≥ 65-years-old age group ( < 0.05) and PGI/PGII were lower in the ≥ 75-years-old age group ( = 0.035) compared to the 35-44-years-old age group. Levels of low-density lipoprotein cholesterol (LDL-C) were higher ( = 0.009) in -infected subjects that were male. LDL-C levels were higher in 55-74-years-old age group ( < 0.05) for -infected subjects and 45-64-years-old age group ( < 0.05) for non-infected subjects compared to 35-44-years-old age group. Hp-IgG level positively correlated with PGI, PGII and G-17 ( < 0.001, < 0.001, = 0.006), and negatively correlated with PGI/PGII ( < 0.001). Creatinine positively correlated with PGI, PGII and G-17 ( < 0.001, < 0.001, < 0.001). Fasting blood glucose (FBG) positively correlated with PGI/PGII and G-17 ( < 0.001, = 0.037). Age positively correlated with PGII and G-17 ( = 0.005, = 0.026).
PGII levels increased while PGI/PGII declined with age in a healthy population. infection had an effect on raising LDL-C levels to increase the risk of atherosclerosis in males, especially those of elderly age. Age, infection, levels of renal function and FBG were associated with levels of pepsinogens and gastrin.
观察健康人群中胃生物标志物水平随年龄的变化和 () 感染的影响，并探讨与胃生物标志物相关的因素。
选择 395 例受试者，进行体检、生化检查及血清胃蛋白酶原（PG）I 和 II、胃泌素-17（G-17）和 抗体水平检测。采用 Student's -test、ANOVA、Pearson 相关和多元线性回归进行分析。
与 35-44 岁年龄组相比，≥65 岁年龄组的 PGII 水平较高（ < 0.05），≥75 岁年龄组的 PGI/PGII 水平较低（ = 0.035）。低密度脂蛋白胆固醇（LDL-C）水平较高（ = 0.009）的男性感染 。与 35-44 岁年龄组相比，感染组的 55-74 岁年龄组（ < 0.05）和非感染组的 45-64 岁年龄组（ < 0.05）的 LDL-C 水平较高。Hp-IgG 水平与 PGI、PGII 和 G-17 呈正相关（ < 0.001， < 0.001， = 0.006），与 PGI/PGII 呈负相关（ < 0.001）。肌酐与 PGI、PGII 和 G-17 呈正相关（ < 0.001， < 0.001， < 0.001）。空腹血糖（FBG）与 PGI/PGII 和 G-17 呈正相关（ < 0.001， = 0.037）。年龄与 PGII 和 G-17 呈正相关（ = 0.005， = 0.026）。
在健康人群中，PGII 水平随年龄增长而升高，PGI/PGII 水平下降。感染会升高 LDL-C 水平，增加老年男性发生动脉粥样硬化的风险。年龄、感染、肾功能和 FBG 水平与胃蛋白酶原和胃泌素水平相关。
