Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620943671. doi: 10.1177/1076029620943671.
Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidity and mortality in patients with COVID-19, it is unclear whether preexisting differences in coagulation impact the severity of COVID-19. African Americans have higher rates of COVID-19 infection and disease-related morbidity and mortality. Moreover, African Americans are known to be at a higher risk for thrombotic events due to both biological and socioeconomic factors. In this review, we explore whether differences in baseline coagulation status and medical management of coagulation play an important role in COVID-19 disease severity and contribute to racial disparity trends within COVID-19.
严重急性呼吸综合征冠状病毒 2 感染（COVID-19）已知可引起严重的炎症和凝血系统激活，导致血栓前状态。尽管已经表明炎症状态和特定器官疾病是 COVID-19 患者发病率和死亡率的重要决定因素，但尚不清楚是否存在凝血方面的差异会影响 COVID-19 的严重程度。非裔美国人 COVID-19 感染率和与疾病相关的发病率和死亡率较高。此外，由于生物学和社会经济因素，非裔美国人发生血栓事件的风险更高。在这篇综述中，我们探讨了基线凝血状态的差异以及凝血的医疗管理是否在 COVID-19 疾病严重程度中发挥重要作用，并探讨其是否导致 COVID-19 中的种族差异趋势。
