Division of Biomedical Sciences, Indian Council of Medical Research, Jamia Hamdard, New Delhi, India.
Department of Toxicology, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi, India.
Indian J Med Res. 2023 Apr;157(4):281-292. doi: 10.4103/ijmr.ijmr_1538_22.
Venous thromboembolism (VTE), which entails the formation of a thrombus (blood clot) in a vein, has a significant disease burden worldwide. While VTE has traditionally been considered to predominantly affect Caucasian populations, recent studies have indicated a gradual shift in the disease burden towards Asian populations, with added significance of it being a key driver of post-operative mortality. It is imperative to develop a sound understanding of the various factors that affect VTE in stratified local populations. However, there is a glaring paucity of quality data on VTE and its ramifications among Indians - both in terms of quality of life and cost of healthcare. This review aims to throw light on the disease burden, epidemiology, risk factors, environmental factors, food and nutrition that plays a key role in VTE. We also explored the association of VTE with coronavirus disease 2019 to grasp the interplay between the two most significant public health crises of our time. It is vital to place a special emphasis on future research on VTE in India to plug the gaps, which exist in our current knowledge of the disease, particularly with respect to Indian population.
静脉血栓栓塞症(VTE)是指静脉中血栓的形成,它在全球范围内造成了巨大的疾病负担。虽然 VTE 传统上被认为主要影响白种人群体,但最近的研究表明,疾病负担逐渐向亚洲人群转移,而且它还是术后死亡率的一个重要驱动因素。了解影响分层当地人群中 VTE 的各种因素至关重要。然而,在印度,无论是在生活质量还是医疗保健成本方面,VTE 及其后果的高质量数据都严重缺乏。本综述旨在阐明 VTE 的疾病负担、流行病学、风险因素、环境因素、食物和营养在 VTE 中所起的关键作用。我们还探讨了 VTE 与 2019 年冠状病毒病的关联,以了解这两种当前对公众健康最具重大影响的疾病之间的相互作用。特别强调未来在印度进行 VTE 研究以填补我们目前对该疾病的认识空白至关重要,尤其是针对印度人群。