间充质干细胞来源的外泌体长链非编码 RNA 作为心血管疾病的新型调节因子。
Exosomal lncRNAs from mesenchymal stem cells as the novel modulators to cardiovascular disease.
机构信息
Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
出版信息
Stem Cell Res Ther. 2020 Jul 23;11(1):315. doi: 10.1186/s13287-020-01812-6.
Abstract
AIM
Mesenchymal stem cells (MSCs) have been identified as potential therapeutic candidates for cardiovascular disease (CVD). However, the molecular mechanism underlying their therapeutic effects is unknown.
FINDINGS
Recently, Chen et al. showed that an exosomal lncRNA derived from MSCs protected against cardiomyocyte apoptosis in vivo, which provided new insight into our understanding of the functions of MSCs. Other exosomal lncRNAs from MSCs have been shown to play pivotal roles in the development of CVD.
CONCLUSION
Exosomal lncRNAs are important molecules in the application of MSCs, which reveals, at least in part, the functional mechanism of MSCs.
摘要
目的
间充质干细胞（MSCs）已被确定为心血管疾病（CVD）的潜在治疗候选物。然而，其治疗效果的分子机制尚不清楚。
发现
最近，Chen 等人表明，MSC 衍生的外泌体 lncRNA 可在体内防止心肌细胞凋亡，这为我们理解 MSC 的功能提供了新的视角。来自 MSCs 的其他外泌体 lncRNA 已被证明在 CVD 的发展中发挥关键作用。
结论
外泌体 lncRNA 是 MSC 应用中的重要分子，这至少部分揭示了 MSC 的功能机制。
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