Green F H, Whitehead S, Fox H
J Pathol. 1977 Jun;122(2):55-61. doi: 10.1002/path.1711220202.
In colonic adenocarcinomata abnormalities have been noted in all morphological aspects of the local immune system of the bowel; thus, in such tumours there is a defective production of secretory IgA, a diminished content of secretory component (SC) and a marked decrease in intraepithelial lymphocytes. By contrast, no such abnormalities were noted in the non-neoplastic areas of the bowel, either immediately adjacent to, or some distance from, the carcinoma. These findings suggest that there is not usually any generalised morphological abnormality of the local immune systems in intestinal neoplasia and that the immunological abnormalities noted within the tumour are a result of the changed nature of the epithelium, thus altering, or interfering with, the normal interactions between epithelial and lymphoid tissue in the gut.
在结肠腺癌中，已发现肠道局部免疫系统的所有形态学方面均存在异常；因此，在这类肿瘤中，分泌型IgA产生缺陷，分泌成分（SC）含量减少，上皮内淋巴细胞显著减少。相比之下，在紧邻癌灶或距癌灶有一定距离的肠道非肿瘤区域未发现此类异常。这些发现表明，肠道肿瘤形成时局部免疫系统通常不存在任何全身性形态学异常，肿瘤内所观察到的免疫异常是上皮性质改变的结果，从而改变或干扰了肠道上皮与淋巴组织之间的正常相互作用。
