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2
Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound.来自海洋放线菌的蛋白酶抑制剂作为抗疟化合物的潜在来源。
PLoS One. 2014 Mar 11;9(3):e90972. doi: 10.1371/journal.pone.0090972. eCollection 2014.
3
Are they really lost? "true" status and reasons for treatment discontinuation among HIV infected patients on antiretroviral therapy considered lost to follow up in Urban Malawi.他们真的失联了吗?马拉维城市中,抗逆转录病毒治疗中被认为失联的艾滋病毒感染者的“真实”状态和治疗中断原因。
PLoS One. 2013 Sep 26;8(9):e75761. doi: 10.1371/journal.pone.0075761. eCollection 2013.
4
Failure to initiate antiretroviral therapy, loss to follow-up and mortality among HIV-infected patients during the pre-ART period in Uganda.乌干达抗逆转录病毒治疗前时期感染 HIV 的患者未能开始抗逆转录病毒治疗、失访和死亡。
J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):e64-71. doi: 10.1097/QAI.0b013e31828af5a6.
5
Virological failure and drug resistance in patients on antiretroviral therapy after treatment interruption in Lilongwe, Malawi.马拉维利隆圭中断抗逆转录病毒治疗后患者的病毒学失败和耐药性。
Clin Infect Dis. 2012 Aug;55(3):441-8. doi: 10.1093/cid/cis438. Epub 2012 May 9.
6
Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions.资源有限环境下感染 HIV 患者的护理保留率:新的见解和新方向。
Curr HIV/AIDS Rep. 2010 Nov;7(4):234-44. doi: 10.1007/s11904-010-0061-5.
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Early active follow-up of patients on antiretroviral therapy (ART) who are lost to follow-up: the 'Back-to-Care' project in Lilongwe, Malawi.抗逆转录病毒疗法(ART)失访患者的早期主动随访:马拉维利隆圭的“回归关怀”项目。
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8
Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach.采用抽样方法了解非洲抗逆转录病毒治疗项目中患者失访的原因和结果。
J Acquir Immune Defic Syndr. 2010 Mar;53(3):405-11. doi: 10.1097/QAI.0b013e3181b843f0.
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Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis.资源有限环境下抗逆转录病毒治疗项目中失访患者的死亡率:系统评价与荟萃分析
PLoS One. 2009 Jun 4;4(6):e5790. doi: 10.1371/journal.pone.0005790.
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Improvement of the patient flow in a large urban clinic with high HIV seroprevalence in Kampala, Uganda.乌干达坎帕拉一家艾滋病毒血清阳性率高的大型城市诊所患者流程的改善。
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艾滋病管理服务的留存率:真的很低吗?以喀麦隆雅温得中心医院为例。

Retention in HIV/AIDS Management Services: is it Really Poor? The Case of Yaounde Central Hospital in Cameroon.

作者信息

Kouanfack Charles, Bede Fala, Nkfusai Claude Ngwayu, Wepngong Emerson, Venyuy Mbinkar Adeline, Hubert Chombong, Sam Denise Movuh, Cumber Samuel Nambile

机构信息

Department of Public Health, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Cameroon.

Day Hospital, Hopital Central Yaounde, Cameroon.

出版信息

Int J MCH AIDS. 2020;9(2):207-212. doi: 10.21106/ijma.305. Epub 2020 May 6.

DOI:10.21106/ijma.305
PMID:32704407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7370274/
Abstract

BACKGROUND

After consecutively defaulting on their appointments for three months, many HIV positive patients are often reported to have defaulted on their treatment, become lost to follow-up (LTFU), or no longer in care. We sought to determine if retention in HIV/AIDS care and treatment is really poor.

METHODS

Outcomes of patients with missed clinic appointments and reasons for missing appointments were studied. We sampled adult HIV positive patients on antiretroviral therapy (ART) who by clinic had missed their clinic appointments by more than four weeks between 1997 and 2019 at the HIV Care and Treatment Center (CTC) (Day Hospital) of the Yaoundé Central Hospital. We assumed that patients who missed their clinic appointment also missed some doses of their ART medications. Patients considered LTFU and those who had defaulted for two months were traced by telephone calls and home visits. Reasons for ART discontinuation were recorded for those who stopped or interrupted ART.

RESULTS

Of the 1139 patients who were either LTFU or who had defaulted for two months, 247/1139 (22 %) could not be traced. Out of the successfully traced patients, 50 (4%) had died and 798/1139 (70%) were alive and 310/1139 (27%) were on ART of which 35/1139 (3%) had developed informal ways of obtaining ART through clinic personnel. A good number were brought back to and reinitiated on ART after tracking (540/1139 or 47%). Of those known not to be on treatment(ART), 27/1139 (2%) had deliberately stopped ART and 63/1139 (6%) promised to return and took an appointment with CTC pyscho-social workers. Major reasons shared for missing clinic appointments were travel out of city (39%), distance from health facility, and financial cost for getting to health facility.

CONCLUSION AND GLOBAL HEALTH IMPLICATIONS

Despite clinic data showing many patients had missed monthly appointments or were LTFU, we saw that a sizeable amount of such patients were actually in care and on ART. The above findings lead to the suggestion that clinic data used in program performance evaluation may not always reflect the true picture retention in care for persons in HIV/AIDS programs at hospital and national levels.

摘要

背景

据报告,许多艾滋病毒呈阳性的患者连续三个月未按预约就诊后,往往中断治疗、失访或不再接受治疗。我们试图确定艾滋病毒/艾滋病护理和治疗的留存率是否真的很低。

方法

研究了错过门诊预约的患者的结局以及错过预约的原因。我们对雅温得中心医院艾滋病毒护理和治疗中心(日间医院)1997年至2019年间因门诊而错过门诊预约四周以上的接受抗逆转录病毒治疗(ART)的成年艾滋病毒阳性患者进行了抽样。我们假设错过门诊预约的患者也错过了一些剂量的ART药物。通过电话和家访追踪那些被视为失访以及那些已违约两个月的患者。记录了那些停止或中断ART治疗的患者停止治疗的原因。

结果

在1139名失访或违约两个月的患者中,247/1139(22%)无法追踪到。在成功追踪到的患者中,50名(4%)已经死亡,798/1139(70%)还活着,310/1139(27%)正在接受ART治疗,其中35/1139(3%)通过诊所工作人员找到了获取ART的非正式途径。在追踪后,相当一部分患者被带回并重新开始接受ART治疗(540/1139或47%)。在那些已知未接受治疗(ART)的患者中,27/1139(2%)故意停止了ART治疗,63/1139(6%)承诺返回并与CTC心理社会工作者预约。错过门诊预约的主要原因是出城旅行(39%)、距离医疗机构较远以及前往医疗机构的经济成本。

结论及对全球健康的影响

尽管诊所数据显示许多患者错过了每月的预约或失访,但我们发现相当数量的此类患者实际上正在接受护理和ART治疗。上述发现表明,用于项目绩效评估的诊所数据可能并不总是反映医院和国家层面艾滋病毒/艾滋病项目中患者护理留存的真实情况。