请吃掉（只是一部分）我：突触磷酯酰丝氨酸提示小胶质细胞大快朵颐：两项新研究确定了一种常见的凋亡细胞标志如何被用来塑造神经回路。
Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast: Two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits.
机构信息
Department of Psychiatry, Perelman School of Medicine, Philadelphia, PA, USA.
Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
EMBO J. 2020 Aug 17;39(16):e105924. doi: 10.15252/embj.2020105924. Epub 2020 Jul 23.
Abstract
Microglia, the brain's tissue-resident macrophages, contribute to the developmental elimination of extranumerary synapses and to pathologic synapse loss in mouse models of neurodegeneration. Two papers published in The EMBO Journal reveal that phosphatidylserine (PS) is a neuronal cue for microglial synapse elimination.
摘要
小胶质细胞是大脑组织中的常驻巨噬细胞，它们有助于发育过程中多余突触的消除，并有助于神经退行性变的小鼠模型中病理性突触的丧失。发表在《欧洲分子生物学组织杂志》上的两篇论文揭示了磷脂酰丝氨酸（PS）是神经元发出的小胶质细胞清除突触的信号。
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