First Department of Neurosurgery, AHEPA University Hospital, Aristotle University of Thessaloniki , Thessaloniki, Greece.
Laboratory of Mechanics and Materials, Polytechnic School, Aristotle University of Thessaloniki , Thessaloniki, Greece.
Neurol Res. 2020 Dec;42(12):1018-1026. doi: 10.1080/01616412.2020.1796381. Epub 2020 Jul 24.
Brain gliomas represent some of the most aggressive tumors encountered by modern medicine and, despite major efforts to optimize early diagnosis and treatment, the prognosis remains poor. Due to the complex structure of the brain and the unique mechanical properties of the extracellular matrix, gliomas invade and expand into the brain parenchyma, along white matter tracts and within perivascular spaces, usually sparing normal vessels. Different methods have been developed to study the mechanical properties of gliomas in a wide range of scales, from cells and the microscale to tissues and the macroscale. In this review, the current view on glioma mechanics is presented and the methods used to determine glioma mechanical properties are outlined. Their principles and current state of affairs are discussed.
脑胶质瘤是现代医学所面临的最具侵袭性的肿瘤之一，尽管已经做出了巨大的努力来优化早期诊断和治疗，但预后仍然不佳。由于大脑的复杂结构和细胞外基质的独特力学性质，胶质瘤会沿着白质束和血管周围间隙侵入并扩展到脑实质中，通常不会损伤正常血管。已经开发出不同的方法来研究从细胞和微观尺度到组织和宏观尺度的广泛范围内的胶质瘤的力学特性。在这篇综述中，呈现了目前对胶质瘤力学的看法，并概述了用于确定胶质瘤力学特性的方法。讨论了它们的原理和现状。
