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当前用于胶质瘤治疗的光动力疗法:最新进展

Current Photodynamic Therapy for Glioma Treatment: An Update.

作者信息

Aebisher David, Przygórzewska Agnieszka, Myśliwiec Angelika, Dynarowicz Klaudia, Krupka-Olek Magdalena, Bożek Andrzej, Kawczyk-Krupka Aleksandra, Bartusik-Aebisher Dorota

机构信息

Department of Photomedicine and Physical Chemistry, Medical College of the Rzeszów University, 35-959 Rzeszów, Poland.

English Division Science Club, Medical College of the Rzeszów University, 35-025 Rzeszów, Poland.

出版信息

Biomedicines. 2024 Feb 6;12(2):375. doi: 10.3390/biomedicines12020375.

DOI:10.3390/biomedicines12020375
PMID:38397977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10886821/
Abstract

Research on the development of photodynamic therapy for the treatment of brain tumors has shown promise in the treatment of this highly aggressive form of brain cancer. Analysis of both in vivo studies and clinical studies shows that photodynamic therapy can provide significant benefits, such as an improved median rate of survival. The use of photodynamic therapy is characterized by relatively few side effects, which is a significant advantage compared to conventional treatment methods such as often-used brain tumor surgery, advanced radiotherapy, and classic chemotherapy. Continued research in this area could bring significant advances, influencing future standards of treatment for this difficult and deadly disease.

摘要

用于治疗脑肿瘤的光动力疗法的研究已显示出在治疗这种极具侵袭性的脑癌方面的前景。对体内研究和临床研究的分析表明,光动力疗法可带来显著益处,比如提高中位生存率。光动力疗法的使用特点是副作用相对较少,与常用的脑肿瘤手术、先进放疗和经典化疗等传统治疗方法相比,这是一个显著优势。该领域的持续研究可能会带来重大进展,影响这种疑难致命疾病未来的治疗标准。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b76/10886821/61a30c964c8b/biomedicines-12-00375-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b76/10886821/11bd8e6b08a6/biomedicines-12-00375-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b76/10886821/ae189c837007/biomedicines-12-00375-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b76/10886821/61a30c964c8b/biomedicines-12-00375-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b76/10886821/11bd8e6b08a6/biomedicines-12-00375-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b76/10886821/ae189c837007/biomedicines-12-00375-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b76/10886821/61a30c964c8b/biomedicines-12-00375-g003.jpg

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Macrophages as a photosensitizer delivery system for photodynamic therapy: Potential for the local treatment of resected glioblastoma.巨噬细胞作为光动力疗法的光敏剂递送系统:用于切除的脑胶质瘤局部治疗的潜力。
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Single-cell analysis of 5-aminolevulinic acid intraoperative labeling specificity for glioblastoma.
推进癌症治疗与诊断:关于使用OLED技术的光动力疗法的综述
Molecules. 2025 Mar 14;30(6):1305. doi: 10.3390/molecules30061305.
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Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis.通过受体介导的转胞吞作用利用大分子靶向脑药物递送。
Pharmaceutics. 2025 Jan 15;17(1):109. doi: 10.3390/pharmaceutics17010109.
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Molecular Determinants for Photodynamic Therapy Resistance and Improved Photosensitizer Delivery in Glioma.用于光动力疗法耐药性的分子决定因素和脑胶质瘤中光敏剂传递的改进。
Int J Mol Sci. 2024 Aug 9;25(16):8708. doi: 10.3390/ijms25168708.
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Preliminary investigation of nitric oxide release from upconverted nanoparticles excited at 808 nm near-infrared for brain tumors.808纳米近红外光激发的上转换纳米颗粒用于脑肿瘤时一氧化氮释放的初步研究
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单细胞分析 5-氨基酮戊酸术中标记物对胶质母细胞瘤的特异性。
J Neurosurg. 2023 Sep 22;140(4):968-978. doi: 10.3171/2023.7.JNS23122. Print 2024 Apr 1.
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