Machado Marta Evangelho, Porto Luis C, Nogueira Jeane S, Sant Anna Clemax C, Lapa E Silva José R
Universidade Federal do Rio de Janeiro (UFRJ), Programa de Pós-graduação em Clínica Médica (PPGCM - HU), Rio de Janeiro, RJ, Brazil; Fundação Técnico-Educacional Souza Marques, Departamento de Pediatria - Pólo Itanhangá, Rio de Janeiro, RJ, Brazil.
Universidade do Estado do Rio de Janeiro (UERJ), Laboratório de Histocompatibilidade e Criopreservação (HLA - PPC), Rio de Janeiro, RJ, Brazil.
J Pediatr (Rio J). 2025 Jan-Feb;101(1):89-95. doi: 10.1016/j.jped.2024.07.006. Epub 2024 Aug 16.
To describe independent factors related to the interaction of FTO rs9939609, TMEM18 rs6548238, leptin, and adiponectin in children/adolescents with asthma, under the influence of obesity.
The authors performed a cross-sectional study with 57 children/adolescents, ages 8-19 years, at a tertiary hospital, from 2017 to 2018. Participants were classified by nutritional status, performed spirometry with a bronchodilator test and completed an asthma questionnaire, higher scores indicated more asthma symptoms. Two asthma groups were formed: Group 1(G1)-normal-weight; Group 2(G2)-overweight/obese. Serum was collected for adipokines (n = 32) and genetic polymorphisms (n = 53) dosages.
Age and body mass index (BMI) correlated directly in normal-weight (p = 0.009) and obese participants (p = 0.004). Girls reported more asthma complaints (p = 0.044). Participants with negative bronchodilator responses presented lower BMI (14.55-17.16) than responders (19.4-26.84) (p = 0.049). Leptin dosages are related directly to BMI (5,34-40 ng/ml in obese × 0,54-42 ng/ml in nonobese) (p = 0.003). Levels were high in girls (4.78-17.55 µg/ml) (p = 0.029) and low in nonobese boys (0.54-6.92 µg/ml) (p = 0.006). In obese, low leptin levels (< 10 ng/ml) were found in small airway dysfunction carriers (p = 0.025); elevated adiponectin (> 5 µg/ml) correlated with FEV1/FVC > 80 % (p = 0.035) and positive bronchodilator tests (8.84-13 µg/ml) (p = 0.039); and FTO A allele correlated with low adiponectin 0-8.84 µg/ml (p = 0.021) and low FEV1/FVC (46 %-88 %) (p = 0.023).
BMI correlated directly with age and leptin levels. Obese participants presented high serum levels of leptin and FTO A allele correlated with low FEV1/FVC. Larger cohorts are necessary for better elucidation of the role of adipokines and polymorphisms in the pathophysiology of asthma and obesity.
描述在肥胖影响下，儿童/青少年哮喘患者中与FTO rs9939609、TMEM18 rs6548238、瘦素和脂联素相互作用相关的独立因素。
作者于2017年至2018年在一家三级医院对57名8至19岁的儿童/青少年进行了一项横断面研究。参与者按营养状况分类，进行了支气管扩张试验的肺功能测定，并完成了一份哮喘问卷，得分越高表明哮喘症状越多。形成了两个哮喘组：第1组（G1）——正常体重；第2组（G2）——超重/肥胖。采集血清用于检测脂肪因子（n = 32）和基因多态性（n = 53）剂量。
年龄与体重指数（BMI）在正常体重参与者（p = 0.009）和肥胖参与者（p = 0.004）中呈正相关。女孩报告的哮喘症状更多（p = 0.044）。支气管扩张试验反应为阴性的参与者的BMI（14.55 - 17.16）低于反应为阳性的参与者（19.4 - 26.84）（p = 0.049）。瘦素剂量与BMI直接相关（肥胖者为5.34 - 40 ng/ml，非肥胖者为0.54 - 42 ng/ml）（p = 0.003）。女孩的瘦素水平较高（4.78 - 17.55 µg/ml）（p = 0.029），非肥胖男孩的瘦素水平较低（0.54 - 6.92 µg/ml）（p = 0.006）。在肥胖者中，小气道功能障碍携带者的瘦素水平较低（< 10 ng/ml）（p = 0.025）；脂联素升高（> 5 µg/ml）与FEV1/FVC > 80%（p = 0.035）和支气管扩张试验阳性（8.84 - 13 µg/ml）相关（p = 0.039）；FTO A等位基因与低水平脂联素0 - 8.84 µg/ml（p = 0.021）和低FEV1/FVC（46% - 88%）相关（p = 0.023）。
BMI与年龄和瘦素水平直接相关。肥胖参与者的血清瘦素水平较高，FTO A等位基因与低FEV1/FVC相关。需要更大的队列来更好地阐明脂肪因子和多态性在哮喘和肥胖病理生理学中的作用。
