School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Chem Commun (Camb). 2020 Sep 7;56(69):9950-9953. doi: 10.1039/d0cc03157g. Epub 2020 Jul 24.
The cultivation of single crystals from solution is usually a time-consuming trial-and-error process. Here, we report a general strategy for rapidly cultivating single crystals from melt microdroplets within tens of minutes at the microgram scale. This strategy was successfully applied to the important polymorphic system griseofulvin to provide missing structural information of Form III, for which single crystals could not be cultivated from solution, as well as to twenty clinical drugs to verify its generality.
从溶液中培养单晶通常是一个耗时的反复试验过程。在这里，我们报告了一种在微升级规模下，在数十分钟内从熔体微滴中快速培养单晶的通用策略。该策略成功应用于灰黄霉素这一重要的多晶型体系，提供了无法从溶液中培养单晶的 III 型结构的缺失信息，以及二十种临床药物，以验证其通用性。
