Catalysis Laboratory School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India.
Chem Asian J. 2020 Oct 1;15(19):2960-2983. doi: 10.1002/asia.202000731. Epub 2020 Aug 27.
The small heterocyclic ring of the 1,2,3-triazole module is one of the most widely investigated compounds in numerous applications of biological, medicinal, pharmaceutical and materially important molecules. In this regard, a large number of synthetic methodologies and approaches have already been reported to construct such a heterocyclic core structure in a selective manner. However, the vinyl-substituted 1,2,3-triazole moiety is another privileged segment in heterocyclic chemistry. The selective introduction of simple vinyl and functionalized vinyl groups onto the three different positions of the 1,2,3-triazole framework can significantly improve the properties of the molecule. Accordingly, high-yielding efficient approaches for the selective construction of vinyl-containing 1,2,3-triazoles becomes a promising branch of chemistry among practitioners of industry and academia. In this minireview, we have discussed recent advances in the construction of highly selective three different vinyl-containing 1,2,3-triazoles. In addition, representative synthetic methodologies and approaches for the corresponding three different classes of vinyl-1,2,3-triazoles and their applications have been described as well in this review.
1,2,3-三唑模块的小杂环是在生物、医学、药物和具有重要意义的物质分子的众多应用中研究最广泛的化合物之一。在这方面，已经有大量的合成方法和途径被报道用于以选择性的方式构建这种杂环核心结构。然而，乙烯基取代的 1,2,3-三唑部分是杂环化学中的另一个重要部分。在 1,2,3-三唑骨架的三个不同位置上选择性地引入简单的乙烯基和官能化的乙烯基基团可以显著改善分子的性质。因此，高效地选择性构建含乙烯基的 1,2,3-三唑的方法成为工业界和学术界实践者中很有前途的化学分支。在这篇综述中，我们讨论了构建高选择性的三种不同含乙烯基 1,2,3-三唑的最新进展。此外，还描述了相应的三种不同类型的乙烯基-1,2,3-三唑及其应用的代表性合成方法和途径。
