University of Gdańsk, Faculty of Biology, Department of Medical Biology and Genetics, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Medical University of Gdańsk, Faculty of Medicine, Department of Hypertension and Diabetology, Dębinki 7, 80-211 Gdańsk, Poland.
Diabetes Res Clin Pract. 2020 Aug;166:108337. doi: 10.1016/j.diabres.2020.108337. Epub 2020 Jul 21.
Charcot neuroarthropathy is a chronic, progressive condition of the skeletal system that affects some patients with diabetic neuropathy. It results in progressive destruction of bones of the foot and disorganisation of pedal joints and ligaments. Effective prevention and treatment for Charcot neuroarthropathy remain a challenge. Currently, there are no reliable repeatable markers to identify patients with diabetes who are at higher risk of developing Charcot neuroarthropathy. The pathogenesis underlying the development of Charcot neuroarthropathy also remains unclear. In this review, we provide an overview of the history, prevalence, symptoms, risk factors, diagnostics and treatment of Charcot neuroarthropathy. We also discuss the potential for OPG and RANKL gene variants to act as predictive markers for the development of Charcot neuroarthropathy. Finally, we summarise the latest research on the role of monocyte-to-osteoclast differentiation in the development of acute Charcot neuroarthropathy.
夏科氏神经关节病是一种影响部分糖尿病性周围神经病患者的慢性、进行性骨骼系统疾病。它导致足部骨骼的进行性破坏以及足关节和韧带的紊乱。夏科氏神经关节病的有效预防和治疗仍然是一个挑战。目前，没有可靠的可重复标志物来识别发生夏科氏神经关节病风险较高的糖尿病患者。夏科氏神经关节病发展的发病机制仍不清楚。在这篇综述中，我们概述了夏科氏神经关节病的历史、流行率、症状、危险因素、诊断和治疗。我们还讨论了 OPG 和 RANKL 基因突变作为预测夏科氏神经关节病发展的标志物的潜力。最后，我们总结了单核细胞向破骨细胞分化在急性夏科氏神经关节病发展中的最新研究。
