Dubský Michal, Bém Robert, Sojáková Dominika, Fejfarová Vladimira, Hughes Michael, Jude Edward B
Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
First Faculty of Medicine, Charles University, Prague, Czech Republic.
Drugs Aging. 2025 Aug 11. doi: 10.1007/s40266-025-01234-0.
Charcot neuropathic osteoarthropathy (CNO) is a condition that develops in the presence of neuropathy, most commonly diabetes-related neuropathy. Owing to the neuropathy, microtrauma to the bones occur without the individual feeling them. With continued walking, bone inflammation, resorption, microfractures and structural changes occur in the bones, which result in irreversible deformities. Diagnosing this condition is often difficult and requires advanced imaging techniques, such as scintigraphy or magnetic resonance imaging, as X-ray changes may not be specific. Treatment of CNO includes immobilization, offloading, recalcification (supplementation of vitamin D and calcium) and in the most advanced cases, surgical treatment. This narrative review aims to synthesize the recent research and clinical implications relating to Charcot foot to help healthcare professionals to stay up-to-date in this relevant topic.
夏科特神经性骨关节病（CNO）是一种在存在神经病变的情况下发生的病症，最常见的是与糖尿病相关的神经病变。由于神经病变，骨骼会受到微创伤，而个体却没有感觉。随着持续行走，骨骼会出现炎症、吸收、微骨折和结构变化，从而导致不可逆转的畸形。诊断这种病症通常很困难，需要先进的成像技术，如闪烁扫描或磁共振成像，因为X线改变可能不具有特异性。CNO的治疗包括固定、减负、重新钙化（补充维生素D和钙），在最严重的情况下还包括手术治疗。本叙述性综述旨在综合与夏科特足相关的最新研究和临床意义，以帮助医疗保健专业人员了解这一相关主题的最新情况。
