靶向癌症中的信号转导和转录激活因子3（STAT3）及信号转导和转录激活因子5（STAT5）
Targeting STAT3 and STAT5 in Cancer.
作者信息
de Araujo Elvin D, Keserű György M, Gunning Patrick T, Moriggl Richard
机构信息
Centre for Medicinal Chemistry, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.
Department of Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.
出版信息
Cancers (Basel). 2020 Jul 22;12(8):2002. doi: 10.3390/cancers12082002.
Abstract
Insights into the mutational landscape of the human cancer genome coding regions defined about 140 distinct cancer driver genes in 2013, which approximately doubled to 300 in 2018 following advances in systems cancer biology studies [...].
摘要
2013年，对人类癌症基因组编码区突变图谱的深入研究确定了约140个不同的癌症驱动基因，随着系统癌症生物学研究的进展，到2018年这一数字大约翻了一番，达到300个[……]
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