Bacova Kristina, Zitterl-Eglseer Karin, Chrastinova Lubica, Laukova Andrea, Madarova Michaela, Gancarcikova Sona, Sopkova Drahomira, Andrejcakova Zuzana, Placha Iveta
Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Physiology, Soltesovej 4-6, 040 01 Kosice, Slovakia.
Institute of Animal Nutrition and Functional Plant Compounds, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Wien, Austria.
Animals (Basel). 2020 Jul 22;10(8):1248. doi: 10.3390/ani10081248.
Thymol concentrations in rabbit plasma, intestinal wall (IW) and faeces were detected, and the effects of thymol application and withdrawal on biochemical, antioxidant parameters and fatty acids (FA) in blood (B) and muscle (M) were studied. Forty-eight rabbits were divided into two experimental groups (control, C and with thymol 250-mg/kg feed, T). Thymol was administered for 21 days (TA) and withdrawn for seven days (TW). Thymol in plasma correlated with that in the IW (Spearman's correlation coefficient (r) = -1.000, = 0.0167, TA) and was detected in faeces (TA and TW). In TA alkaline phosphatase ( = 0.0183), cholesterol ( = 0.0228), malondialdehyde ( = 0.003), glutathione peroxidase ( = 0.0177) in B and lactate dehydrogenase (M, = 0.0411) decreased; monounsaturated FA ( = 0.0104) and α-linolenic acid ( = 0.0227) in M increased. In TW urea ( = 0.0079), docosapentaenoic acid ( = 0.0069) in M increased; linoleic acid ( = 0.0070), ∑ n-6 ( = 0.0007) in M and triglycerides decreased (B, = 0.0317). In TA and TW, the total protein ( = 0.0025 and 0.0079), creatinine (B; = 0.0357 and 0.0159) and oleic acid (M; = 0.0104 and 0.0006) increased. Thymol was efficiently absorbed from the intestine and demonstrated its biological activity in blood and the muscles.
检测了兔血浆、肠壁（IW）和粪便中的百里香酚浓度，并研究了百里香酚的施用和撤药对血液（B）和肌肉（M）中的生化、抗氧化参数及脂肪酸（FA）的影响。48只兔子被分为两个实验组（对照组，C和添加250 mg/kg饲料百里香酚组，T）。百里香酚给药21天（TA），撤药7天（TW）。血浆中的百里香酚与肠壁中的百里香酚相关（斯皮尔曼相关系数（r）=-1.000，P = 0.0167，TA），且在粪便中检测到（TA和TW）。在TA期，B中的碱性磷酸酶（P = 0.0183）、胆固醇（P = 0.0228）、丙二醛（P = 0.003）、谷胱甘肽过氧化物酶（P = 0.0177）以及M中的乳酸脱氢酶（P = 0.0411）降低；M中的单不饱和脂肪酸（P = 0.0104）和α-亚麻酸（P = 0.0227）增加。在TW期，M中的尿素（P = 0.0079）、二十二碳五烯酸（P = 0.0069）增加；M中的亚油酸（P = 0.0070）、∑n-6（P = 0.0007）以及B中的甘油三酯降低（P = 0.
