Division of Endocrinology and Metabolism, Rostock University Medical Center, 18057 Rostock, Germany.
Department of Internal, Autoimmune and Metabolic Diseases, Medical Faculty in Katowice, Medical University of Silesia, 40-055 Katowice, Poland.
Int J Mol Sci. 2020 Jul 22;21(15):5200. doi: 10.3390/ijms21155200.
The majority of patients with diabetes mellitus (DM) have hypertension (HTN). A specific mechanism for the development of HTN in DM has not been described. In the Zucker, Endothel, und Salz (sugar, endothelium, and salt) study (ZEuS), indices of glucose metabolism and of volume regulation are recorded. An analysis of these parameters shows that glucose concentrations interfere with plasma osmolality and that changes in glycemic control have a significant impact on fluid status and blood pressure. The results of this study are discussed against the background of the striking similarities between the regulation of sugar and salt blood concentrations, introducing the view that DM is probably a sodium-retention disorder that leads to a state of hypervolemia.
大多数糖尿病（DM）患者都有高血压（HTN）。DM 中 HTN 发展的特定机制尚未描述。在 Zucker、Endothel 和 Salz（糖、内皮和盐）研究（ZEuS）中，记录了葡萄糖代谢和体积调节的指数。对这些参数的分析表明，葡萄糖浓度会干扰血浆渗透压，血糖控制的变化对液体状态和血压有重大影响。本研究结果以糖和盐血浓度调节之间惊人的相似性为背景进行了讨论，提出了 DM 可能是一种钠潴留障碍，导致高血容量状态的观点。
