Siegenthaler Joëlle, Pleyers Tekla, Raillard Mathieu, Spadavecchia Claudia, Levionnois Olivier Louis
Section of Anaesthesiology and Pain Therapy, Department of Clinical Veterinary Sciences, Vetsuisse Faculty, University of Berne, 3012 Bern, Switzerland.
University Veterinary Teaching Hospital, School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney 2006, Australia.
Animals (Basel). 2020 Jul 21;10(7):1240. doi: 10.3390/ani10071240.
The objectives were: (1) to compare the antinociceptive activity of dexmedetomidine and medetomidine, and (2) to investigate its modulation by atipamezole. This prospective, randomized, blinded experimental trial was carried out on eight beagles. During the first session, dogs received either medetomidine (MED) (0.02 mg kg intravenously (IV)] or dexmedetomidine (DEX) [0.01 mg kg IV), followed by either atipamezole (ATI) (0.1 mg kg) or an equivalent volume of saline (SAL) administered intramuscularly 45 min later. The opposite treatments were administered in a second session 10-14 days later. The nociceptive withdrawal reflex (NWR) threshold was determined using a continuous tracking approach. Sedation was scored (0 to 21) every 10 min. Both drugs (MED and DEX) increased the NWR thresholds significantly up to 5.0 (3.7-5.9) and 4.4 (3.9-4.8) times the baseline ( = 0.547), at seven (3-11) and six (4-9) minutes ( = 0.938), respectively. Sedation scores were not different between MED and DEX during the first 45 min (15 (12-17), = 0.67). Atipamezole antagonized sedation within 25 (15-25) minutes ( = 0.008) and antinociception within five (3-6) minutes ( = 0.008). Following atipamezole, additional analgesics may be needed to maintain pain relief.
（1）比较右美托咪定和美托咪定的镇痛活性，（2）研究阿替美唑对其的调节作用。本前瞻性、随机、双盲实验研究在8只比格犬身上进行。在第一阶段，犬只静脉注射美托咪定（MED）（0.02 mg/kg）或右美托咪定（DEX）（0.01 mg/kg），45分钟后肌肉注射阿替美唑（ATI）（0.1 mg/kg）或等量生理盐水（SAL）。10 - 14天后的第二阶段给予相反的处理。使用连续追踪方法测定伤害性退缩反射（NWR）阈值。每10分钟进行镇静评分（0至21分）。两种药物（MED和DEX）分别在7（3 - 11）分钟和6（4 - 9）分钟时使NWR阈值显著提高至基线的5.0（3.7 - 5.9）倍和4.4（3.9 - 4.8）倍（P = 0.547）。在前45分钟内，MED和DEX的镇静评分无差异（15（12 - 17），P = 0.67）。阿替美唑在25（15 - 25）分钟内拮抗镇静作用（P = 0.008），在5（3 - 6）分钟内拮抗镇痛作用（P = 0.008）。使用阿替美唑后，可能需要额外的镇痛药来维持疼痛缓解。
