Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Molecules. 2020 Jul 16;25(14):3252. doi: 10.3390/molecules25143252.
This review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant importance in the field of medicinal chemistry because many of them exhibit a great variety of biological activities. First, the published strategies related to the synthesis of 1,5-naphthyridines are presented followed by the reactivity of these compounds with electrophilic or nucleophilic reagents, in oxidations, reductions, cross-coupling reactions, modification of side chains or formation of metal complexes. Finally, some properties and applications of these heterocycles studied during this period are examined.
本综述涵盖了过去 18 年中发表的 1,5-萘啶衍生物的合成和反应性。这些杂环在药物化学领域具有重要意义，因为其中许多具有多种生物活性。首先，介绍了与 1,5-萘啶合成相关的已发表策略，然后介绍了这些化合物与亲电或亲核试剂、氧化还原反应、交叉偶联反应、侧链修饰或形成金属配合物的反应性。最后，考察了在此期间研究的这些杂环的一些性质和应用。
