State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, 610500, Xindu, People's Republic of China.
School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, 610500, People's Republic of China.
Top Curr Chem (Cham). 2021 Feb 24;379(2):13. doi: 10.1007/s41061-020-00314-6.
The burgeoning interest in synthesis and biological applications of 1,6-naphthyridines reflects the importance of 1,6-naphthyridines in the synthetic as well as medicinal chemistry fields. Specially, 1,6-naphthyridines are pharmacologically active, with variety of applications such as anticancer, anti-human immunodeficiency virus (HIV), anti-microbial, analgesic, anti-inflammatory and anti-oxidant activities. Although collective recent synthetic developments have paved a path to a wide range of functionalized 1,6-naphthyridines, a complete correlation of synthesis with biological activity remains elusive. The current review focuses on recent synthetic developments from the last decade and a thorough study of the anticancer activity of 1,6-naphthyridines on different cancer cell lines. Anticancer activity has been correlated to 1,6-naphthyridines using the literature on the structure-activity relationship (SAR) along with molecular modeling studies. Exceptionally, at the end of this review, the utility of 1,6-naphthyridines displaying activities other than anticancer has also been included as a glimmering extension.
1,6-萘啶衍生物的合成和生物应用的兴起反映了其在合成化学和药物化学领域的重要性。特别地，1,6-萘啶衍生物具有药理活性，具有多种应用，如抗癌、抗人类免疫缺陷病毒 (HIV)、抗菌、镇痛、抗炎和抗氧化活性。尽管最近的综合发展为各种功能化的 1,6-萘啶衍生物铺平了道路，但合成与生物活性之间的完全相关性仍然难以捉摸。本综述重点介绍了过去十年的最新合成进展，并对不同癌细胞系中 1,6-萘啶衍生物的抗癌活性进行了深入研究。抗癌活性已通过文献中的构效关系 (SAR) 以及分子建模研究与 1,6-萘啶衍生物相关联。特别地，在本综述的最后，还包括了除抗癌活性以外的具有其他活性的 1,6-萘啶衍生物的应用，作为一个闪光的扩展。
