Department of Obstetrics and Gynecology, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
Department of Obstetrics and Gynecology, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
Fertil Steril. 2020 Aug;114(2):407-415. doi: 10.1016/j.fertnstert.2020.03.043. Epub 2020 Jul 22.
To assess the psychosocial outcomes of recipients and their partners 2 and 3 years after entering this first clinical uterus transplantation study.
Prospective observational study.
University hospital.
PATIENT(S): Nine women with absolute uterine factor infertility and their male partners participated.
INTERVENTION(S): Psychosocial evaluations using questionnaires focusing on health-related quality-of-life, mood, relationship, and fertility-related quality-of-life were conducted at 2- and 3-year follow-up after transplantation.
MAIN OUTCOME MEASURE(S): Scores were obtained on the validated questionnaires 36-Item Short Form Survey (SF-36), Hospital Anxiety and Depression Scale, Dyadic Adjustment Scale, and Fertility Quality of life measuring health-related quality-of-life, mood, relationship, and infertility-associated life quality, respectively.
RESULT(S): There was a reversible decrease (at year 2) in the physical component of SF-36 concerning recipients, but not in partners. Negative deviations in the mental component of SF-36 were seen in four recipients, and in two of their partners at year 3, possibly related to the fact that live birth had not been achieved yet among three of these women. Childlessness also seemed to be related to reporting elevated anxiety scores. Most recipients and partners stated high satisfaction with marital relationship both at inclusion and at follow-up.
CONCLUSION(S): The results of the present study show that even if the baseline psychosocial characteristics of the women to undergo transplantation and their partners were stable and equal or better compared with norm populations, graft failure and failure to achieve parenthood will pose psychological strains on couples in the period up to 3 years after transplantation. Psychological counseling should be offered past 3 years for recipients and their partners.
NCT01844362.
评估接受者及其伴侣在进入这项首次临床子宫移植研究 2 年和 3 年后的心理社会结局。
前瞻性观察性研究。
大学医院。
9 名患有绝对子宫因素不孕的女性及其男性伴侣参与了该研究。
在移植后 2 年和 3 年进行了使用问卷进行的心理社会评估，重点关注与健康相关的生活质量、情绪、关系和与生育相关的生活质量。
采用经过验证的问卷 36-项短表调查（SF-36）、医院焦虑和抑郁量表、对偶调整量表和生育质量生活量表分别评估与健康相关的生活质量、情绪、关系和与不孕相关的生活质量。
接受者的 SF-36 身体成分在第 2 年可逆性下降（第 2 年），但伴侣没有下降。4 名接受者在第 3 年出现 SF-36 心理成分的负向偏差，其 2 名伴侣也出现这种情况，可能与这 3 名女性中仍未实现活产有关。无法生育似乎也与焦虑评分升高有关。大多数接受者和伴侣在入组时和随访时均表示对婚姻关系非常满意。
本研究结果表明，即使接受移植的女性及其伴侣的心理社会特征在基线时稳定且与常模人群相等或更好，移植物失败和无法实现生育仍将在移植后 3 年内对夫妇造成心理压力。应在 3 年后为接受者及其伴侣提供心理咨询。
NCT01844362。
