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The roles of cytosolic and intramitochondrial Ca and the mitochondrial Ca-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation.胞质和线粒体内钙离子以及线粒体钙离子单向转运体（MCU）在刺激哺乳动物氧化磷酸化过程中的作用。
J Biol Chem. 2020 Jul 24;295(30):10506. doi: 10.1074/jbc.L120.013975.
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Reply to Rutter : The roles of cytosolic and intramitochondrial Ca and the mitochondrial Ca-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation.对拉特的回复：胞质和线粒体内钙以及线粒体钙单向转运体（MCU）在刺激哺乳动物氧化磷酸化中的作用。
J Biol Chem. 2020 Jul 24;295(30):10507. doi: 10.1074/jbc.RL120.014342.
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[The Molecular Mechanisms of Mitochondrial Calcium Uptake by Calcium Uniporter].[钙单向转运体介导线粒体钙摄取的分子机制]
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Control by Ca of mitochondrial structure and function in pancreatic β-cells.钙离子对胰腺β细胞中线粒体结构和功能的调控。
Cell Calcium. 2020 Nov;91:102282. doi: 10.1016/j.ceca.2020.102282. Epub 2020 Sep 1.
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Reply to Rutter : The roles of cytosolic and intramitochondrial Ca and the mitochondrial Ca-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation.对拉特的回复：胞质和线粒体内钙以及线粒体钙单向转运体（MCU）在刺激哺乳动物氧化磷酸化中的作用。
J Biol Chem. 2020 Jul 24;295(30):10507. doi: 10.1074/jbc.RL120.014342.

本文引用的文献

1
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply.细胞质钙而非线粒体钙对于调节线粒体丙酮酸供应是必需的。
J Biol Chem. 2020 Apr 3;295(14):4383-4397. doi: 10.1074/jbc.RA119.011902. Epub 2020 Feb 24.
2
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.通过缺乏线粒体钙单向转运蛋白的小鼠揭示线粒体钙的生理作用。
Nat Cell Biol. 2013 Dec;15(12):1464-72. doi: 10.1038/ncb2868. Epub 2013 Nov 10.
3
Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells.线粒体钙作为哺乳动物细胞中线粒体ATP生成的关键调节因子。
Biochim Biophys Acta. 2009 Nov;1787(11):1324-33. doi: 10.1016/j.bbabio.2009.01.019. Epub 2009 Feb 3.
4
Studies on the interactions of Ca2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Effects of starvation and diabetes.关于Ca2+与丙酮酸在调节大鼠心脏丙酮酸脱氢酶活性中的相互作用的研究。饥饿和糖尿病的影响。
Biochem J. 1982 Feb 15;202(2):419-27. doi: 10.1042/bj2020419.
5
Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes.钙离子在脑线粒体和突触体中丙酮酸脱氢酶相互转化中的作用。
Biochem J. 1985 Apr 1;227(1):129-36. doi: 10.1042/bj2270129.
6
Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using 31P n.m.r. and ruthenium red.线粒体内钙离子在受刺激大鼠心脏氧化磷酸化调节中作用的直接证据。使用31P核磁共振和钌红的研究。
Biochem J. 1989 Aug 15;262(1):293-301. doi: 10.1042/bj2620293.
7
Role of calcium ions in regulation of mammalian intramitochondrial metabolism.钙离子在哺乳动物线粒体内代谢调节中的作用。
Physiol Rev. 1990 Apr;70(2):391-425. doi: 10.1152/physrev.1990.70.2.391.

The roles of cytosolic and intramitochondrial Ca and the mitochondrial Ca-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation.

作者信息

Rutter Guy A, McCormack James G, Halestrap Andrew P, Denton Richard M

机构信息

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Department of Metabolism, Reproduction, and Digestion, Imperial College London, London, United Kingdom

Lee Kong Chian School of Medicine, Nan Yang Technological University, Singapore.

出版信息

J Biol Chem. 2020 Jul 24;295(30):10506. doi: 10.1074/jbc.L120.013975.

DOI:10.1074/jbc.L120.013975
PMID:32709760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7383389/
Abstract
摘要