NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Transl Psychiatry. 2020 Jul 24;10(1):251. doi: 10.1038/s41398-020-00931-1.
Human brain development involves spatially and temporally heterogeneous changes, detectable across a wide range of magnetic resonance imaging (MRI) measures. Investigating the interplay between multimodal MRI and polygenic scores (PGS) for personality traits associated with mental disorders in youth may provide new knowledge about typical and atypical neurodevelopment. We derived independent components across cortical thickness, cortical surface area, and grey/white matter contrast (GWC) (n = 2596, 3-23 years), and tested for associations between these components and age, sex and-, in a subsample (n = 878), PGS for neuroticism. Age was negatively associated with a single-modality component reflecting higher global GWC, and additionally with components capturing common variance between global thickness and GWC, and several multimodal regional patterns. Sex differences were found for components primarily capturing global and regional surface area (boys > girls), but also regional cortical thickness. For PGS for neuroticism, we found weak and bidirectional associations with a component reflecting right prefrontal surface area. These results indicate that multimodal fusion is sensitive to age and sex differences in brain structure in youth, but only weakly to polygenic load for neuroticism.
人类大脑的发育涉及空间和时间上的异质变化，可以通过广泛的磁共振成像（MRI）测量来检测。研究多模态 MRI 与与精神障碍相关的人格特质的多基因评分（PGS）之间的相互作用，可能为典型和非典型神经发育提供新的知识。我们在皮质厚度、皮质表面积和灰质/白质对比度（GWC）方面推导出独立成分（n=2596，3-23 岁），并在亚样本（n=878）中测试这些成分与年龄、性别和神经质的 PGS 之间的关联。年龄与反映较高全局 GWC 的单一模式成分呈负相关，并且还与反映全局厚度和 GWC 之间共同方差的成分以及几个多模态区域模式呈负相关。性别差异存在于主要反映全局和区域表面积的成分中（男孩>女孩），但也存在于区域皮质厚度中。对于神经质的 PGS，我们发现与反映右前额叶表面积的成分存在微弱的双向关联。这些结果表明，多模态融合对青少年大脑结构的年龄和性别差异敏感，但对神经质的多基因负荷只有微弱的反应。
