4-氨基-N-2-吡啶基苯磺酰胺（磺胺吡啶）的多晶型IV
Polymorph IV of 4-amino-N-2-pyridinylbenzenesulfonamide (sulfapyridine).
作者信息
Bernstein J
机构信息
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel.
出版信息
Acta Crystallogr C. 1988 May 15;44 ( Pt 5):900-2. doi: 10.1107/s0108270188001180.
C11H11N3O2S, Mr = 249.3, monoclinic, P2(1)/c, a = 13.56 (4), b = 6.48 (1), c = 14.12 (3) A, beta = 113.7 (1) degrees, V = 1136.4 (44) A3, Z = 4, D chi = 1.457 g cm-3, lambda(Mo K alpha) = 0.70926 A, mu = 2.29 cm-1, F(000) = 520, T = 291 K, final R = 0.085 for 1287 independent observed reflections. Sulfapyridine is a sulfonamide drug with antibacterial, antithyroid and antidiabetic properties. The molecule exhibits the same conformation as in all except one of the polymorphs previously studied, despite a hydrogen-bonded packing mode which differs from that observed in the three earlier reported polymorphs. Form IV exhibits three hydrogen bonds of the type N...N = 2.91 (1) A and N...O = 3.007 (7) and 3.076 (7) A.
C₁₁H₁₁N₃O₂S，Mr = 249.3，单斜晶系，P2(1)/c，a = 13.56(4)，b = 6.48(1)，c = 14.12(3) Å，β = 113.7(1)°，V = 1136.4(44) ų，Z = 4，Dχ = 1.457 g cm⁻³，λ(Mo Kα) = 0.70926 Å，μ = 2.29 cm⁻¹，F(000) = 520，T = 291 K，对于1287个独立观测反射，最终R = 0.085。磺胺吡啶是一种具有抗菌、抗甲状腺和抗糖尿病特性的磺胺类药物。尽管氢键堆积模式与之前报道的三种多晶型物中观察到的不同，但该分子呈现出与之前研究的所有多晶型物（除一种外）相同的构象。IV型呈现出三种类型的氢键，N...N = 2.91(1) Å以及N...O = 3.007(7)和3.076(7) Å。
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