Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain; Department of Analytical Chemistry, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Spain.
Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain; Department of Analytical Chemistry, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Spain; Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Spain.
Sci Total Environ. 2020 Nov 20;744:140710. doi: 10.1016/j.scitotenv.2020.140710. Epub 2020 Jul 9.
The main objective of the present research was to evaluate the levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (dl-PCBs) in the human milk of Spanish lactating women who participated in the BETTERMILK project so that exposure and risk could be assessed for these mothers and their breastfed children. The total ∑PCDD/Fs + dl-PCBs TEQ concentrations in the upper-bound (UB) ranged from 1.29 to 13.48 pgTEQ g lipid. The estimated geometric mean level for the sum of PCDD/F and dl-PCBs was 4.10 and 4.42 pgTEQ g lipid, lower-bound (LB) and UB respectively and were below the reference level reported by EFSA, which is associated with adverse effects in boys of 9 years and related to lactating mothers' exposure values of the tolerable weekly intake (TWI) of around 2 pgTEQ kg bw per week. Nevertheless, it was exceeded when the 95th percentile (8.31 pgTEQ g lipid, as UB) was considered. Results from a multiple regression analysis showed that age has a significant impact on milk ∑PCDD/Fs + dl-PCBs levels, with higher concentrations observed in the milk from older mothers.
本研究的主要目的是评估参与 BETTERMILK 项目的西班牙哺乳期妇女母乳中的多氯二苯并对二恶英（PCDDs）、多氯二苯并呋喃（PCDFs）和类似二恶英的多氯联苯（dl-PCBs）水平，以便评估这些母亲及其母乳喂养婴儿的暴露和风险。上限（UB）中总∑PCDD/Fs+dl-PCBs TEQ 浓度范围为 1.29 至 13.48 pgTEQ g 脂质。PCDD/F 和 dl-PCBs 总和的估计几何平均值分别为 4.10 和 4.42 pgTEQ g 脂质，分别为 LB 和 UB，低于 EFSA 报告的与 9 岁男孩不良影响相关的参考水平，与哺乳期母亲可耐受每周摄入量（TWI）的暴露值有关，约为每周 2 pgTEQ kg bw。然而，当考虑到 95 百分位（8.31 pgTEQ g 脂质，UB）时，这一水平就会超标。多元回归分析的结果表明，年龄对母乳中∑PCDD/Fs+dl-PCBs 水平有显著影响，年龄较大的母亲母乳中的浓度更高。
