Department of Neonatology, CHU Sainte-Justine, Quebec, Canada.
The Rotunda Hospital, Dublin and Royal College of Surgeons, Dublin, Ireland.
Clin Perinatol. 2020 Sep;47(3):563-574. doi: 10.1016/j.clp.2020.05.011. Epub 2020 May 20.
Many observational studies have shown that infants with blood pressures (BPs) that are in the lower range for their gestational age tend to have increased complications such as an increased rate of significant intraventricular hemorrhage and adverse long-term outcome. This relationship does not prove causation nor should it create an indication for treatment. However, many continue to intervene with medication for low BP on the assumption that an increase in BP will result in improved outcome. Only adequately powered prospective randomized controlled trials can answer the question of whether individual treatments of low BP are beneficial.
许多观察性研究表明，血压处于胎龄较低范围的婴儿往往会出现更多并发症，例如显著的脑室内出血发生率增加和不良的长期预后。这种关系并不能证明因果关系，也不应该成为治疗的指征。然而，许多人仍然继续使用药物来治疗低血压，假设血压升高会改善预后。只有足够大的前瞻性随机对照试验才能回答低血压个体治疗是否有益的问题。
