Liao Jingping, Wang Ning, Ma Mengying, Lu Tianlan, Yan Hao, Yue Weihua
Institute of Mental Health, The Sixth Hospital, Peking University, Beijing, China.
National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University) & Chinese Academy of Medical Sciences Research Unit (No.2018RU006), Beijing, China.
Front Psychiatry. 2020 Jul 2;11:617. doi: 10.3389/fpsyt.2020.00617. eCollection 2020.
To explore the association of methylenetetrahydrofolate reductase () C677T polymorphism with risperidone-induced weight gain.
We analyzed the association between C677T polymorphism and risperidone-induced weight gain in 356 schizophrenia patients. The patients were treated with risperidone for 8 weeks. The height and body weight of the patients were measured before and 8 weeks after risperidone treatment. Blood DNA was genotyped for C677T polymorphisms.
We found a significant association between C677T polymorphism and body mass index (BMI) change after 8-week risperidone treatment. The BMI of carriers with different genotypes of gene increased over 2-8 weeks. After 8 weeks of risperidone treatment, BMI added value (kg/m) of CC or CT genotype carriers was significantly higher than that of TT genotype carriers [CC (4.47 ± 1.09), CT (4.54 ± 1.27), TT (2.31 ± 0.75), F = 5.634, P = 0.001]. Based on whether the rate of weight gain from baseline at 8 weeks of treatment exceeded 7%, it was divided into a weight gain group (n = 61) and a non-weight gain group (n = 295). The C allele frequency was significantly different between the two groups (48.4% vs 32.4%, = 11.342, P = 0.001).
C677T polymorphism was associated with risperidone-induced weight gain in Chinese Han population.
探讨亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性与利培酮所致体重增加之间的关联。
我们分析了356例精神分裂症患者中MTHFR C677T基因多态性与利培酮所致体重增加之间的关联。患者接受利培酮治疗8周。在利培酮治疗前及治疗8周后测量患者的身高和体重。对血液DNA进行MTHFR C677T基因多态性基因分型。
我们发现MTHFR C677T基因多态性与利培酮治疗8周后的体重指数（BMI）变化之间存在显著关联。不同基因型的MTHFR基因携带者的BMI在2 - 8周内增加。利培酮治疗8周后，CC或CT基因型携带者的BMI增加值（kg/m）显著高于TT基因型携带者[CC（4.47±1.09），CT（4.54±1.27），TT（2.31±0.75），F = 5.634，P = 0.001]。根据治疗8周时体重较基线增加的速率是否超过7%，将患者分为体重增加组（n = 61）和非体重增加组（n = 295）。两组之间的C等位基因频率存在显著差异（48.4%对32.4%，χ² = 11.342，P = 0.001）。
在中国汉族人群中，MTHFR C677T基因多态性与利培酮所致体重增加有关。
