Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China.
Psychiatr Danub. 2014 Jun;26(2):145-51.
The leptin -2548G/A (rs7799039) gene polymorphism has been implicated in susceptibility to antipsychotic-induced weight gain (AIWG), but study results are still controversial. The present meta-analysis was performed to investigate the relationship between the leptin -2548G/A gene polymorphism and AIWG.
Electronic databases were searched for eligible articles in English and Chinese and seven separate studies on the association of the leptin -2548G/A gene polymorphism with AIWG were analyzed.
The meta-analysis involved 451 AIWG patients and 568 controls. The pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were calculated by a fixed or random effect. Overall, our meta-analysis suggests that the leptin -2548G/A gene polymorphism was not significantly associated with AIWG risk under various genetic models. But, in the subgroup analysis by ethnicity, significant association was found between leptin -2548A allele and the AIWG risk in Asian populations under additive, dominant, recessive, and homozygote genetic model. On the contrary, in European populations, the -2548A allele seemed to decrease the risk of AIWG when compared with the -2548G allele under various genetic models, even though they were not statistically significant.
Our meta-analysis suggests that the correlation between leptin -2548G/A gene polymorphism and AIWG risk has significant racial differences.
瘦素-2548G/A（rs7799039）基因多态性与抗精神病药引起的体重增加（AIWG）易感性有关，但研究结果仍存在争议。本荟萃分析旨在探讨瘦素-2548G/A 基因多态性与 AIWG 之间的关系。
检索英文和中文电子数据库中符合条件的文章，并对 7 项关于瘦素-2548G/A 基因多态性与 AIWG 关联的研究进行分析。
荟萃分析共纳入 451 例 AIWG 患者和 568 例对照。采用固定或随机效应模型计算合并优势比（OR）及其相应的 95%置信区间（CI）。总体而言，我们的荟萃分析表明，在各种遗传模型下，瘦素-2548G/A 基因多态性与 AIWG 风险无显著相关性。但是，按种族进行亚组分析时，在加性、显性、隐性和纯合遗传模型下，瘦素-2548A 等位基因与亚洲人群 AIWG 风险之间存在显著关联。相反，在欧洲人群中，与瘦素-2548G 等位基因相比，-2548A 等位基因在各种遗传模型下似乎降低了 AIWG 的风险，尽管这并不具有统计学意义。
本荟萃分析表明，瘦素-2548G/A 基因多态性与 AIWG 风险之间的相关性存在显著的种族差异。
