Chaiyasate Saisawat, Salee Parichat, Sukapan Kornkanok, Teeranoraseth Tanyathorn, Roongrotwattanasiri Kannika
Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Ann Med Surg (Lond). 2020 Jul 15;57:41-45. doi: 10.1016/j.amsu.2020.07.013. eCollection 2020 Sep.
Rhinofacial entomophthoramycosis is a specific fungal infection of the skin and subcutaneous tissue. It is considered as a rare and neglected disease in tropical and subtropical areas. We would like to present our cases to aid other physicians in the improved recognition of typical cases.
A retrospective review was performed on patients with the diagnosis of Conidiobolomycosis or Entomophthoramycosis in Chiang Mai University Hospital, Thailand, from January 2009 to May 2019. There were seven cases with a definite pathologic report or culture in this review.
All seven patients were men and were referred to the university hospital for diagnosis. The mean age was 53 ± 15.7, ranging from 27 to 71 years. Most of the patients (85.7%) presented first with nasal or rhinofacial swelling and nasal obstruction. The definite diagnosis came from clinical presentation and investigation with a tissue biopsy, culture and communication among physicians. Patients responded well with a combination of medical treatment, including potassium iodide (KI), co-trimoxazole, or itraconazole.
Rhinofacial entomophthoromycosis or Conidiobolomycosis typically can be diagnosed under a suspicious clinical presentation. The obvious clinical response can be seen within several weeks after medication.
鼻面部虫霉病是一种皮肤和皮下组织的特异性真菌感染。它在热带和亚热带地区被视为一种罕见且被忽视的疾病。我们希望展示我们的病例，以帮助其他医生更好地识别典型病例。
对2009年1月至2019年5月在泰国清迈大学医院诊断为耳霉病或虫霉病的患者进行回顾性研究。本研究中有7例有明确的病理报告或培养结果。
所有7例患者均为男性，均因诊断问题转诊至大学医院。平均年龄为53±15.7岁，范围为27至71岁。大多数患者（85.7%）最初表现为鼻或鼻面部肿胀及鼻塞。明确诊断来自临床表现、组织活检、培养以及医生之间的沟通。患者对包括碘化钾（KI）、复方新诺明或伊曲康唑在内的联合药物治疗反应良好。
鼻面部虫霉病或耳霉病通常在可疑的临床表现下即可诊断。用药后几周内可见明显的临床反应。
