Chadaram Srinivas, Chappity Preetam, Hallur Vinaykumar, Sharma Prity, Pradeep Pradhan, Parida Pradipta
Ear, Nose, and Throat Department, All India Institute of Medical Sciences, Bhubaneswar, India.
Microbiology Department, All India Institute of Medical Sciences, Bhubaneswar, India.
Oman Med J. 2022 Nov 30;37(6):e448. doi: 10.5001/omj.2022.29. eCollection 2022 Nov.
This paper reviews our institutional experience in the management of rhino-facial entomophthoromycosis, a rare subcutaneous fungal infection. We adopt a fixed two-phase protocol comprising an initial 'intensive phase' (two-drug regimen) followed by an 'eradication phase' (monotherapy). We present five patients treated between May 2013 and May 2020 in our institution who were subjected to the mentioned protocol. All five patients received six months of supersaturated potassium iodide solution and itraconazole, followed by four months of monotherapy with only supersaturated potassium iodide solution. All patients responded well to the treatment and were disease-free on follow-up of a minimum two years post-treatment. We recommend this procedure for all typical cases of entomophthoromycosis and suggest avoiding surgical intervention which may disseminate the fungus and delay response to treatment.
本文回顾了我们机构在鼻面部虫霉病（一种罕见的皮下真菌感染）管理方面的经验。我们采用了固定的两阶段方案，包括初始的“强化阶段”（两药联合疗法），随后是“根除阶段”（单一疗法）。我们介绍了2013年5月至2020年5月期间在我们机构接受上述方案治疗的5例患者。所有5例患者均接受了6个月的过饱和碘化钾溶液和伊曲康唑治疗，随后仅用过饱和碘化钾溶液进行4个月的单一疗法治疗。所有患者对治疗反应良好，治疗后至少随访两年均无疾病复发。我们建议对所有典型的虫霉病病例采用此方法，并建议避免可能传播真菌并延迟治疗反应的手术干预。
