Pravder Harrison D, Hodzic Emina, Bhatla Puneet, Busovsky-McNeal Melissa, Nielsen James C
Division of Pediatric Cardiology, Department of Pediatrics, NYU Langone Health, New York, NY, USA.
Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Pediatr Cardiol. 2020 Dec;41(8):1617-1622. doi: 10.1007/s00246-020-02419-7. Epub 2020 Jul 26.
An established echocardiographic (echo) standard for assessing the newborn right ventricle (RV) for hypertrophy has not been thoroughly developed. This is partially due to the RV's complex architecture, which makes quantification of RV mass by echo difficult. Here, we retrospectively evaluate the thickness of the inferior RV wall (iRVWT) by echo in neonates and infants with normal cardiopulmonary physiology. Inferior RVWT was defined at the medial portion of the inferior wall of the RV at the mid-ventricular level, collected from a subxiphoid, short axis view. iRVWT was indexed to body surface area (BSA) to the 0.5 power and normalized to iLVWT to explore the best normalization method. Ninety-eight neonates and 32 infants were included in the final analysis. Mean age for neonates and infants was 2 days and 59 days, respectively. Mean ± SD for neonate and infant end-diastole iRVWT was 2.17 ± 0.35 mm and 1.79 ± 0.28 mm, respectively. There was no residual relationship between the index iRVWT and BSA (r = 0.03, p = NS). In the infant cohort, the iRVWT was significantly lower and iLVWT was significantly higher compared to neonate, consistent with known physiologic changes of RV and LV mass. Thus, iRVWT may serve as a reliable and accurate proxy for RV mass and the parameter warrants further evaluation.
用于评估新生儿右心室（RV）肥厚的超声心动图（echo）标准尚未完全建立。部分原因是右心室结构复杂，使得通过超声心动图对右心室质量进行量化变得困难。在此，我们回顾性评估了心肺生理正常的新生儿和婴儿经超声心动图测量的右心室下壁厚度（iRVWT）。iRVWT定义为右心室下壁在心室中部水平的内侧部分，从剑突下短轴视图采集。iRVWT根据体表面积（BSA）进行指数化至0.5次方，并与左心室下壁厚度（iLVWT）进行归一化，以探索最佳归一化方法。最终分析纳入了98例新生儿和32例婴儿。新生儿和婴儿的平均年龄分别为2天和59天。新生儿和婴儿舒张末期iRVWT的平均值±标准差分别为2.17±0.35mm和1.79±0.28mm。iRVWT指数与BSA之间无残余相关性（r = 0.03，p =无显著性差异）。在婴儿队列中，与新生儿相比，iRVWT显著更低，iLVWT显著更高，这与已知的右心室和左心室质量的生理变化一致。因此，iRVWT可能是右心室质量的可靠且准确的替代指标，该参数值得进一步评估。
