Misir Sema, Hepokur Ceylan, Aliyazicioglu Yüksel, Enguita Francisco J
Department of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, 58140, Sivas, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080, Trabzon, Turkey.
Breast Cancer. 2020 Nov;27(6):1048-1057. doi: 10.1007/s12282-020-01140-w. Epub 2020 Jul 26.
Circular RNAs are a large group of non-coding RNAs with a closed-loop structure. circRNAs play significant roles in many biological processes as miRNA sponges, regulators for gene transcription, combining with RNA-binding proteins and translation of protein. Nowadays, circRNAs have become a research hotspot in the field of cancer and molecular biology. Accumulating evidences have indicated that circRNAs participate in the initiation and development of various cancers such as breast cancer. Breast cancer is a heterogeneous disease, which is the most common malignancy in women. The incidence and mortality rates of breast cancer indicate that it is the leading cause of cancer-related deaths. The goal of the present review is to introduce biogenesis, function characteristics and types of circRNAs, and also their biological functions on breast cancer, especially as miRNA sponges. Additionally, we discuss their use as a new therapeutic target for the treatment of breast cancer.
环状RNA是一大类具有闭环结构的非编码RNA。环状RNA作为微小RNA海绵、基因转录调节因子、与RNA结合蛋白结合以及蛋白质翻译，在许多生物学过程中发挥着重要作用。如今，环状RNA已成为癌症和分子生物学领域的研究热点。越来越多的证据表明，环状RNA参与了各种癌症如乳腺癌的发生和发展。乳腺癌是一种异质性疾病，是女性中最常见的恶性肿瘤。乳腺癌的发病率和死亡率表明它是癌症相关死亡的主要原因。本综述的目的是介绍环状RNA的生物发生、功能特征和类型，以及它们在乳腺癌中的生物学功能，特别是作为微小RNA海绵的功能。此外，我们还讨论了它们作为乳腺癌治疗新靶点的应用。
